ArticleZhongguo fei ai za zhi = Chinese journal of lung cancer2014
[Effects of tumor suppressor gene TCF21 on the proliferation, migration and apoptosis of A549 cells].
Article in Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction.Cell death & disease · 2022Article
- Deficient or R273H and R248W Mutations of p53 Promote Chemoresistance to 5-FUFrontiers in cell and developmental biology · 2021Article
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5 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectiveTCF21, a newly discovered gene, exhibits tumor suppressor function in a variety of tumors. This study aims to observe the effects of TCF21 on the proliferation, apoptosis and migration of A549 human lung adenocarcinoma epithelial cells.
methodsTCF21 was overexpressed in A549 cells via lentiviral transfection. Fluorescence-based quantitative polymerase chain reaction and Western blot analysis were used to analyze the expression of the target gene. Transwell, proliferation assay, and flow cytometry were applied to detect the effect of TCF21 overexpression on the migration, proliferation, and apoptosis of A549 cells after transfection.
resultsThe proliferation and migration of A549 cells were inhibited, and the apoptotic rate was increased by overexpressing TCF21.
conclusionsThe tumor suppressor gene, TCF21, significantly inhibits the proliferation and migration, as well as facilitates early apoptosis of A549 cells.
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