ArticleJournal of the American Chemical Society2014
Palau'chlor: a practical and reactive chlorinating reagent.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
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- Catalytic electrophilic arene C-H chlorination by rethinking the century-old Willgerodt reagent.Nature communications · 2026Article
- Aromaticity and structure switching of cyclopropametallaindole to metallaquinolinium.Nature communications · 2026Article
- One-Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade.Angewandte Chemie (International ed. in English) · 2026Article
- Nitrosonium Ion-Catalyzed Oxidative Chlorination of Arenes.The Journal of organic chemistry · 2026Article
- Visible-light promoted late-stage chlorination and bromination of quinones and (hetero)arenes utilizing aqueous HCl or HBr as halogen donors.Communications chemistry · 2025Article
- Mechanistic Insight into the Thermal Ring Opening of the Dewar Isomer of 1,2-Dihydro-1,2-azaborinines.JACS Au · 2025Article
- Separation of halide oxidation and substrate halogenation chemistries rationalizes site-selective vanadium dependent haloperoxidase catalysis.bioRxiv : the preprint server for biology · 2025Article
- Unveiling an Alternative Mechanism for Lewis Basic Selenium as a C─H Hydrogen Bond Catalyst and Its Application in the Halogenation of Arenes.Angewandte Chemie (International ed. in English) · 2025Article
- Enantioconvergent Cobalt-Catalyzed Hydroalkylation for the Construction of Fluoro, Chloro, and Trifluoromethyl Stereogenic Centers.Angewandte Chemie (International ed. in English) · 2025Article
- Visible-Light-Mediated Vicinal Dihalogenation of Unsaturated C-C Bonds Using Dual-Functional Group Transfer Reagents.Journal of the American Chemical Society · 2024Article
- Repurposing of halogenated organic pollutants via alkyl bromide-catalysed transfer chlorination.Nature chemistry · 2024Article
- Discovery of N-X anomeric amides as electrophilic halogenation reagents.Nature chemistry · 2024Article
- Thianthrene/TfOH-catalyzed electrophilic halogenations usingChemical science · 2024Article
- Intramolecular chaperone-assisted dual-anchoring activation (ICDA): a suitable preorganization for electrophilic halocyclization.Chemical science · 2024Article
- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- A Porphyrin Iron(III) π-Dication Species and its Relevance in Catalyst Design for the Umpolung of Nucleophiles.Angewandte Chemie (International ed. in English) · 2023Article
- Enantioselective Total Synthesis of (+)-KB343.Journal of the American Chemical Society · 2023Article
- Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy.Neuropharmacology · 2023Article
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Authors and funding
6 authors.
Funding
Abstract
Unlike its other halogen atom siblings, the utility of chlorinated arenes and (hetero)arenes are twofold: they are useful in tuning electronic structure as well as acting as points for diversification via cross-coupling. Herein we report the invention of a new guanidine-based chlorinating reagent, CBMG or "Palau'chlor", inspired by a key chlorospirocyclization en route to pyrrole imidazole alkaloids. This direct, mild, operationally simple, and safe chlorinating method is compatible with a range of nitrogen-containing heterocycles as well as select classes of arenes, conjugated π-systems, sulfonamides, and silyl enol ethers. Comparisons with other known chlorinating reagents revealed CBMG to be the premier reagent.
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