ArticleAJR. American journal of roentgenology2014
Safety of ultrasound contrast agents in the pediatric oncologic population: a single-institution experience.
Article in AJR. American journal of roentgenology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Contrast-enhanced voiding urosonography (ceVUS) with the intravesical administration of the ultrasound contrast agent Optison™ for vesicoureteral reflux detection in children: a prospective clinical trial.Pediatric radiology · 2018Trial
- Bubbles in the barely born-contrast-enhanced ultrasound in neonates: a single-center experience.European journal of pediatrics · 2026Article
- Microvascular ultrasound imaging of the neonatal brain: a scoping review.European journal of pediatrics · 2026Article
- Controversies in contrast-enhanced ultrasound (CEUS): pregnancy, paediatric, abdominal trauma, complex renal cysts, and endovascular aortic repair follow-up.Insights into imaging · 2025Article
- Expanding Role of Contrast-Enhanced Ultrasound and Elastography in the Evaluation of Abdominal Pathologies in Children.Diagnostics (Basel, Switzerland) · 2025Review
- Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part I.Diagnostics (Basel, Switzerland) · 2023Review
- Contrast-enhanced subharmonic aided pressure estimation for assessment of intracranial pressure in vivo.Pediatric radiology · 2023Article
- Microbubbles in the belly: optimizing the protocol for contrast-enhanced ultrasound of the pediatric abdomen.Pediatric radiology · 2023Review
- Contrast-Enhanced Ultrasound (CEUS) as an Ancillary Imaging Test for Confirmation of Brain Death in an Infant: A Case Report.Children (Basel, Switzerland) · 2022Article
- Contrast-enhanced ultrasound of the neonatal brain.Pediatric radiology · 2022Review
- Pediatric contrast-enhanced ultrasound: optimization of techniques and dosing.Pediatric radiology · 2021Review
- Contrast-enhanced ultrasound: a comprehensive review of safety in children.Pediatric radiology · 2021Review
- Contrast-enhanced ultrasound of blunt abdominal trauma in children.Pediatric radiology · 2021Review
- Emerging contrast-enhanced ultrasound applications in children.Pediatric radiology · 2021Review
- Differential diagnosis of liver metastases of gastrointestinal stromal tumors from colorectal cancer based on combined tumor biomarker with features of conventional ultrasound and contrast-enhanced ultrasound.Abdominal radiology (New York) · 2020Article
- The role of multiparametric ultrasound in the diagnosis of paediatric scrotal pathology.The British journal of radiology · 2020Review
- Contrast enhanced ultrasound: comparing a novel modality to MRI to assess for bowel disease in pediatric Crohn's patients.Translational gastroenterology and hepatology · 2020Article
- Bedside contrast-enhanced ultrasound diagnosing cessation of cerebral circulation in a neonate: A novel bedside diagnostic tool.The neuroradiology journal · 2018Article
- Clinical Applications of Contrast-Enhanced Ultrasound in the Pediatric Work-Up of Focal Liver Lesions and Blunt Abdominal Trauma: A Systematic Review.Ultrasound international open · 2017Review
- Enhancing the role of paediatric ultrasound with microbubbles: a review of intravenous applications.The British journal of radiology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveLittle information is available regarding the safety of ultrasound contrast agents in children. The purpose of this article was to assess the safety profile of the i.v. administration of ultrasound contrast agents in the pediatric oncology population. MATERIALS AND
methodsPatients with pediatric solid malignancies who were enrolled on institutional clinical trials conducted between June 2003 and January 2013 and who met our institutional screening criteria for contrast-enhanced ultrasound (CEUS) were eligible. After providing informed consent or assent for CEUS, subjects received i.v. bolus injections of one of two contrast agents for imaging of the primary tumor or a metastatic target lesion. Hemodynamic parameters, including heart rate, cardiac rhythm, and oxygen saturation, were monitored immediately before and for 30 minutes after the administration of the contrast agent. Interviews with the subject or a guardian were conducted by the principal investigator or a radiologist coinvestigator before and after the examination to assess for any adverse effects.
resultsThirty-four subjects (21 male and 13 female) ranging in age from 8 months to 20.7 years (median, 8.7 years) underwent 134 CEUS. No detrimental change in hemodynamic status occurred in any subject. Three subjects (3/134, 2.2%) reported mild transient side effects on one occasion each, two (2/134, 1.5%) had taste alteration, and one (1/134, 0.8%) reported mild transient tinnitus and lightheadedness. These reactions did not recur in these subjects on subsequent CEUS examinations.
conclusionThe i.v. administration of ultrasound contrast agents is safe and well tolerated in the pediatric oncology population. Further studies in children are needed to confirm our findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.