ReviewExpert review of cardiovascular therapy2014
Pulmonary arteriovenous malformations after the superior cavopulmonary shunt: mechanisms and clinical implications.
Review in Expert review of cardiovascular therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 65 citations in OpenAlex.
- Vitamin A Uses Its Superpowers to Combat Vascular Malformations.JACC. Basic to translational science · 2026Article
- Transcatheter Management of Congenital and Acquired Venous Lesions in Children.Journal of clinical medicine · 2026Article
- Pulsatile flow dynamics maintain pulmonary artery architecture.JCI insight · 2026Article
- Emerging Techniques and Treatment Outcomes in Pulmonary Arteriovenous Malformations Embolisation: A Narrative Review.Journal of clinical medicine · 2025Review
- Hepatic vein-derived factors may affect pulmonary arteriovenous malformations after single ventricle palliation by modulating vascular cell behavior.Scientific reports · 2025Article
- Early Versus Delayed Bidirectional Superior Cavopulmonary Anastomosis (BSCA) in Infants: A Comparison of Outcomes.Cureus · 2025Article
- Cardiorenal Syndrome in Adults with Congenital Heart Disease.Journal of clinical medicine · 2025Review
- Influence of Simulated Altitude Exposure (2500 m) on Patients with Fontan Palliation Based on Circulating Hypoxia-Associated Factors.International journal of molecular sciences · 2025Article
- Article
- Impact of Age-Related Change in Caval Flow Ratio on Hepatic Flow Distribution in the Fontan Circulation.Circulation. Cardiovascular imaging · 2024Article
- Neurological and cardiopulmonary manifestations of pulmonary arteriovenous malformations.Frontiers in medicine · 2024Review
- Collaterals in congenital heart disease: when and how to treat?Cardiovascular diagnosis and therapy · 2023Review
- Pulmonary Arteriovenous Fistulae After Fontan Operation: Incidence, Clinical Characteristics, and Impact on All-Cause Mortality.Frontiers in pediatrics · 2022Article
- Virtual treatment planning in three patients with univentricular physiology using computational fluid dynamics-Pitfalls and strategies.Frontiers in cardiovascular medicine · 2022Article
- Diagnosis and endovascular management of pulmonary arteriovenous malformations.The British journal of radiology · 2021Review
- Non-uniform mixing of hepatic venous flow and inferior vena cava flow in the Fontan conduit.Journal of the Royal Society, Interface · 2021Article
- Hepatopulmonary Syndrome and Multiple Arteriovenous Fistulas in a Child with Niemann-Pick Disease.Pediatric allergy, immunology, and pulmonology · 2021Article
- Variceal Hemorrhage in Two Children With Congenital Heart Disease and Long-Term Pulmonary Venous Obstruction.JPGN reports · 2021Article
- Commentary: sVEGFR1 Is Enriched in Hepatic Vein Blood-Evidence for a Provisional Hepatic Factor Candidate?Frontiers in pediatrics · 2021Article
- Conversion of prior univentricular repairs to septated circulation: Case selection, challenges, and outcomes.Indian journal of thoracic and cardiovascular surgery · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Children with functional single ventricle heart disease are commonly palliated down a staged clinical pathway toward a Fontan completion procedure (total cavopulmonary connection). The Fontan physiology is fraught with long-term complications associated with lower body systemic venous hypertension, eventually resulting in significant morbidity and mortality. The bidirectional Glenn shunt or superior cavopulmonary connection (SCPC) is commonly the transitional stage in single ventricle surgical management and provides excellent palliation. Some studies have demonstrated lower morbidity and mortality with the SCPC when compared with the Fontan. Unfortunately the durability of the SCPC is significantly limited by the development of pulmonary arteriovenous malformations (PAVMs) which have been commonly attributed to the absence of hepatic venous blood flow and the lack of pulsatile flow to the affected lungs. Abnormal angiogenesis has been suggested as a final common pathway to PAVM development. Understanding these fundamental mechanisms through the investigation of angiogenic pathways associated with the pathogenesis of PAVMs would help to develop medical therapies that could prevent or reverse this complication following SCPC. Such therapies could improve the longevity of the SCPC, potentially eliminate or significantly postpone the Fontan completion with its associated complications, and improve long-term survival in children with single ventricle disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.