Evidence map›Paper›PMID 24757581›Full record

ArticleACS catalysis2014

Mechanistic Studies of Gold and Palladium Cooperative Dual-Catalytic Cross-Coupling Systems.

Mohammad Al-Amin, Katrina E Roth, Suzanne A Blum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Orthogonal tandem catalysis.Nature chemistry · 2015
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mohammad Al-AminDepartment of Chemistry, University of California at Irvine, Irvine, CA 92697-2025, USA.
Katrina E RothDepartment of Chemistry, University of California at Irvine, Irvine, CA 92697-2025, USA.
Suzanne A BlumDepartment of Chemistry, University of California at Irvine, Irvine, CA 92697-2025, USA.
University of California, Irvine · US

Funding

Bond-Forming Methods via Dual-Metal Catalysis with Organogold IntermediatesR01GM098512 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLUM, SUZANNE A. · 2012 to 2015
$1.1M
NIGMS NIH HHS R01 GM098512
6 · The paper itself

Abstract

Double-label crossover, modified-substrate, and catalyst comparison experiments in the gold and palladium dual-catalytic rearrangement/cross-coupling of allenoates were performed in order to probe the mechanism of this reaction. The results are consistent with a cooperative catalysis mechanism whereby 1) gold activates the substrate prior to oxidative addition by palladium, 2) gold acts as a carbophilic rather than oxophilic Lewis acid, 3) competing olefin isomerization is avoided, 4) gold participates beyond the first turnover and therefore does not serve simply to generate the active palladium catalyst, and 5) single-electron transfer is not involved. These experiments further demonstrate that the cooperativity of both gold and palladium in the reaction is essential because significantly lower to zero conversion is achieved with either metal alone in comparison studies that examined multiple potential gold, palladium, and silver catalysts and precatalysts. Notably, employment of the optimized cocatalysts, PPh

Indexed as

Cooperative catalysisCross-couplingCrossoverDual catalysisGold and PalladiumIntermediatesMechanism

Identifiers

PMID24757581
PMCPMC3991925
OpenAlexW2028753420

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.