ReviewSarcoma2014
Brain metastasis in bone and soft tissue cancers: a review of incidence, interventions, and outcomes.
Review in Sarcoma, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Angiosarcoma-related cerebral metastases: a systematic review of the literature.Neurosurgical review · 2020Pooled it
- Hemorrhagic brain metastasis as the initial presentation of osteosarcoma: a rare case report.Oxford medical case reports · 2025Article
- A rare case report of insular metastatic from sarcoma with successful long term surgical and oncological management.International journal of surgery case reports · 2025Article
- Calvarial Chondroplastic Osteosarcoma With Distant Brain Metastasis Treated With Radiosurgery: A Rare Case Report.Case reports in medicine · 2025Article
- Intracranial pleomorphic liposarcoma misclassified as a pleomorphic xanthoastrocytoma by a DNA methylation classifier: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Respiratory insufficiency after brain metastasectomy for extraskeletal Ewing sarcoma in an adult patient with mucopolysaccharidosis type II: a case report.International cancer conference journal · 2024Article
- Case Series of Soft Tissue Sarcoma Patients with Brain Metastasis with Implications from Genomic and Transcriptomic Analysis.Cancer research and treatment · 2024Article
- Unusual presentation of aneurysmal bone cyst (ABC) in children: pediatric intracranial osteosarcoma with secondary ABC.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Brain metastases of sarcoma: a rare phenomenon in rare tumours.Journal of cancer research and clinical oncology · 2023Review
- Intracranial Metastasis of Extracranial Chondrosarcoma: Systematic Review With Illustrative Case.Brain tumor research and treatment · 2023Article
- A retrospective analysis of the prognosis of Japanese patients with sarcoma brain metastasis.Cancer medicine · 2023Article
- Unusual presentation of Ewing sarcoma; a case report and literature review.International journal of surgery case reports · 2022Article
- Sacral Ewing sarcoma with rib, lung, and multifocal skull metastases: A rare case report and review of treatments.Frontiers in oncology · 2022Article
- Brain Metastases from Adult Sarcomas: A Retrospective Cohort Study from the Hellenic Group of Sarcomas and Rare Cancers (HGSRC).Journal of clinical medicine · 2021Article
- Brain Metastases in Patients With Soft-Tissue Sarcomas: Management and Survival-A SEER Population-Based Cohort Study.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2021Article
- Stereotactic radiosurgery as a primary treatment for metastatic skull base alveolar soft part sarcoma: a case report.Acta neurochirurgica · 2021Article
- Surgical outcome and graded prognostic assessment of patients with brain metastasis from adult sarcoma: multi-institutional retrospective study in Japan.International journal of clinical oncology · 2020Article
- Cerebral metastasis from osteosarcoma: "Bone" in the brain.Radiology case reports · 2020Article
- Up-Regulation of circRNA hsa_circ_0003074 Expression is a Reliable Diagnostic and Prognostic Biomarker in Patients with Osteosarcoma.Cancer management and research · 2020Article
- Brain metastases from Truncal and extremity bone and soft tissue sarcoma: Single institution study of oncologic outcomes.Rare tumors · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone and soft tissue malignancies account for a small portion of brain metastases. In this review, we characterize their incidence, treatments, and prognosis. Most of the data in the literature is based on case reports and small case series. Less than 5% of brain metastases are from bone and soft tissue sarcomas, occurring most commonly in Ewing's sarcoma, malignant fibrous tumors, and osteosarcoma. Mean interval from initial cancer diagnosis to brain metastasis is in the range of 20-30 months, with most being detected before 24 months (osteosarcoma, Ewing sarcoma, chordoma, angiosarcoma, and rhabdomyosarcoma), some at 24-36 months (malignant fibrous tumors, malignant peripheral nerve sheath tumors, and alveolar soft part sarcoma), and a few after 36 months (chondrosarcoma and liposarcoma). Overall mean survival ranges between 7 and 16 months, with the majority surviving < 12 months (Ewing's sarcoma, liposarcoma, malignant fibrous tumors, malignant peripheral nerve sheath tumors, angiosarcoma and chordomas). Management is heterogeneous involving surgery, radiosurgery, radiotherapy, and chemotherapy. While a survival advantage may exist for those given aggressive treatment involving surgical resection, such patients tended to have a favorable preoperative performance status and minimal systemic disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.