ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2014
The hepatotoxicity and testicular toxicity induced by arecoline in mice and protective effects of vitamins C and e.
Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Recent Advance on Biological Activity and Toxicity of Arecoline in Edible Areca (Betel) Nut: A Review.Foods (Basel, Switzerland) · 2024Review
- Monosodium Glutamate Effect on The Expression of ɑ7nACHR and ɑ4nACHR Subunits in The Testicular Tissue.International journal of fertility & sterility · 2023Article
- Interactions of Betel Quid Constituents with Drug Disposition Pathways: An Overview.Current drug metabolism · 2023Article
- Cumulative Betel Quid Chewing and the Risk of Significant Liver Fibrosis in Subjects With and Without Metabolic Syndrome.Frontiers in nutrition · 2022Article
- A Positive Relationship between Betel Nut Chewing and Significant Liver Fibrosis in NAFLD Subjects, but Not in Non-NAFLD Ones.Nutrients · 2021Article
- Betel Quid Health Risks of Insulin Resistance Diseases in Poor Young South Asian Native and Immigrant Populations.International journal of environmental research and public health · 2020Review
- The Porphyromonas gingivalis inhibitory effects, antioxidant effects and the safety of a Sri Lankan traditional betel quid - an in vitro study.BMC complementary medicine and therapies · 2020Article
- Consumption of betel quid contributes to sensorineural hearing impairment through arecoline-induced oxidative stress.Scientific reports · 2019Article
- Effect of autophagy-associated proteins on the arecoline-induced liver injury in mice.Experimental and therapeutic medicine · 2018Article
- Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders.International journal of biological sciences · 2018Review
- Systemic effect of arecoline on the gastrointestinal system in oral submucous fibrosis affected wistar rats.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arecoline is a major alkaloid of areca nuts which are widely chewed by southeast Asian and it manifests various toxic effects in different organs of human and animals. In this work, mature mice were treated by vitamins C plus E, arecoline, or both daily for four weeks. The results showed that arecoline significantly increased the levels of serum alkaline phosphatase (ALP), glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and significantly decreased the levels of reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) in the liver tissues. Additionally, the body weight, testis weight, sperm counts, motility and normal sperms also were significantly decreased. The supplement of vitamins C and E can bring the activities of ALP and GPT to normal levels and partially restore the sperm counts compared to the arecoline-treated group but have no other positive effects. In conclusion, the vitamins C and E partially attenuated the arecoline-induced hepatotoxiciy but basically had on protective effects against the arecoline-induced testicular toxicity.
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Registered trials
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