Trial reportDiabetes care2014
Frequency of morning ketosis after overnight insulin suspension using an automated nocturnal predictive low glucose suspend system.
Trial report in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Fear of hypoglycemia in children with type 1 diabetes and their parents: Effect of pump therapy and continuous glucose monitoring with option of low glucose suspend in the CGM TIME trial.Pediatric diabetes · 2021Trial
- Ketone production in children with type 1 diabetes, ages 4-14 years, with and without nocturnal insulin pump suspension.Pediatric diabetes · 2017Trial
- Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.Diabetes care · 2016Trial
- Practical Aspects and Exercise Safety Benefits of Automated Insulin Delivery Systems in Type 1 Diabetes.Diabetes spectrum : a publication of the American Diabetes Association · 2023Article
- ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes.Pediatric diabetes · 2022Article
- Diabetes Technology: Monitoring, Analytics, and Optimal Control.Cold Spring Harbor perspectives in medicine · 2019Review
- Combining continuous glucose monitoring and insulin pumps to automatically tune the basal insulin infusion in diabetes therapy: a review.Biomedical engineering online · 2019Review
- Automated closed-loop control of diabetes: the artificial pancreas.Bioelectronic medicine · 2018Review
- Multivariable Adaptive Artificial Pancreas System in Type 1 Diabetes.Current diabetes reports · 2017Review
- Sensor-Augmented Insulin Pumps and Hypoglycemia Prevention in Type 1 Diabetes.Journal of diabetes science and technology · 2017Review
- The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes.Diabetes care · 2016Article
- Hypoglycemia Prevention and User Acceptance of an Insulin Pump System with Predictive Low Glucose Management.Diabetes technology & therapeutics · 2016Article
- The Hypoglycaemia-Hyperglycaemia Minimizer System in the Management of Type 1 Diabetes.European endocrinology · 2016Review
- The benefits, limitations, and cost-effectiveness of advanced technologies in the management of patients with diabetes mellitus.Journal of diabetes science and technology · 2015Review
- Status of Diabetes Care: "It just doesn't get any better . . . or does it?".Diabetes care · 2014Article
- The artificial pancreas: are we there yet?Diabetes care · 2014Article
- Insulin delivery methods: Past, present and future.International journal of pharmaceutical investigationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess the effect of overnight insulin pump suspension in an automated predictive low glucose suspend system on morning blood glucose and ketone levels in an attempt to determine whether routine measurement of ketone levels is useful when a closed-loop system that suspends insulin delivery overnight is being used. RESEARCH DESIGN AND
methodsData from an in-home randomized trial of 45 individuals with type 1 diabetes (age range 15-45 years) were analyzed, evaluating an automated predictive low glucose pump suspension system in which blood glucose, blood ketone, and urine ketone levels were measured on 1,954 mornings.
resultsOne or more pump suspensions occurred during 744 of the 977 intervention nights (76%). The morning blood ketone level was ≥0.6 mmol/L after 11 of the 744 nights (1.5%) during which a pump suspension occurred and 2 of the 233 nights (0.9%) during which there was no suspension compared with 11 of 977 control nights (1.1%). The morning blood ketone level was ≥0.6 mmol/L after only 2 of 159 nights (1.3%) with a pump suspension exceeding 2 h. Morning fasting blood glucose level was not a good predictor of the presence of blood ketones.
conclusionsRoutine measurement of blood or urine ketones during use of an automated pump suspension system using continuous glucose monitoring, whether threshold based or predictive, is not necessary. Recommendations for checking ketone levels should be no different when a patient is using a system with automated insulin suspension than it is for conventional diabetes self-management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.