Evidence map›Paper›PMID 24757225›Full record

ArticleDiabetes care2014

Closed-loop artificial pancreas systems: physiological input to enhance next-generation devices.

Yogish C Kudva, Rickey E Carter, Claudio Cobelli, Rita Basu, Ananda Basu

Abstract read
In one paragraph

Article in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Effect of Pramlintide on Postprandial Glucose Fluxes in Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2016
    Trial
  3. Trial
  4. Observational
  5. Metabolic Models, in Silico Trials, and Algorithms.Diabetes technology & therapeutics · 2025
    Review
  6. Metabolic Models, in Silico Trials, and Algorithms.Journal of diabetes science and technology · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. A machine-learning approach to predict postprandial hypoglycemia.BMC medical informatics and decision making · 2019
    Article
  14. Diabetes Technology: Monitoring, Analytics, and Optimal Control.Cold Spring Harbor perspectives in medicine · 2019
    Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yogish C KudvaCorresponding author: Ananda Basu, basu.ananda@mayo.edu.
Rickey E Carter
Claudio Cobelli
Rita Basu
Ananda Basu

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
MECHANISMS OF INSULIN RESISTANCE IN MANR01DK029953 · NIDDK · UNIVERSITY OF VIRGINIA · PI BASU, RITA · 1986 to 2024
$11.5M
Ambulatory Artificial Pancreas: merging physiology, behavior, and control designDP3DK094331 · NIDDK · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI BASU, ANANDA, DOYLE, FRANCIS J · 2011 to 2014
$4.6M
MECHANISMS OF INSULIN RESISTANCE in ManR37DK029953 · NIDDK · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI RIZZA, ROBERT A. · 1996 to 2003
$1.8M
NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1-TR000135NIDDK NIH HHS DK-029953NIDDK NIH HHS DK-DP3-094331NIDDK NIH HHS DK-R01-085561NIDDK NIH HHS R01 DK029953NIDDK NIH HHS R37 DK029953
6 · The paper itself

Abstract

To provide an understanding of both the preclinical and clinical aspects of closed-loop artificial pancreas systems, we provide a discussion of this topic as part of this two-part Bench to Clinic narrative. Here, the Bench narrative provides an in-depth understanding of insulin-glucose-glucagon physiology in conditions that mimic the free-living situation to the extent possible in type 1 diabetes that will help refine and improve future closed-loop system algorithms. In the Clinic narrative, Doyle and colleagues compare and evaluate technology used in current closed-loop studies to gain further momentum toward outpatient trials and eventual approval for widespread use.

Indexed as

AlgorithmsBlood GlucoseCircadian RhythmDiabetes Mellitus, Type 1EatingExerciseGlucagonGonadal Steroid HormonesHumansHyperglycemiaHypoglycemiaInsulinInsulin Infusion SystemsPancreas, ArtificialStress, PsychologicalBlood GlucoseGlucagonGonadal Steroid HormonesInsulin

Identifiers

PMID24757225
PMCPMC3994931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.