Evidence map›Paper›PMID 24756878›Full record

ArticleInternational journal of epidemiology2014

Exchangeability in the case-crossover design.

Murray A Mittleman, Elizabeth Mostofsky

Abstract read
In one paragraph

Article in International journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  17. Exposure to daily mean and maximum 1-hour PMEnvironmental epidemiology (Philadelphia, Pa.) · 2025
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Murray A MittlemanCardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA and Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA and Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA mmittlem@bidmc.harvard.edu.
Elizabeth MostofskyCardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA and Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA and Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.

Funding

Effect of Ambient Particles on Acute Stroke OnsetP01ES009825 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GOLD, DIANE R · 1999 to 2009
$17.4M
CVD Epidemiology Training Program in Behavior, the Environment and Global HealthT32HL098048 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Goodarz Danaei, ERIC B RIMM · 2009 to 2026
$6.9M
Bereavement and Cardiovascular Events: A Nationwide Prospective Study in SwedenF32HL120505 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MOSTOFSKY, ELIZABETH · 2013 to 2013
$54k
NHLBI NIH HHS HL-F32-120505NHLBI NIH HHS HL-T32-098048NIEHS NIH HHS P01-ES009825
6 · The paper itself

Abstract

In cohort and case-control studies, confounding that arises as a result of differences in the distribution of determinants of the outcome between exposure groups leading to non-exchangeability are addressed by restriction, matching or with statistical models. In case-only studies, this issue is addressed by comparing each individual with his/herself. Although case-only designs use self-matching and only include individuals who develop the outcome of interest, issues of non-exchangeability are identical to those that arise in traditional case-control and cohort studies. In this review, we describe one type of case-only design, the case-crossover design, and discuss how the concept of exchangeability can be used to understand issues of confounding, carryover effects, period effects and selection bias in case-crossover studies.

Indexed as

Confounding Factors, EpidemiologicResearch DesignSelection BiasCase-Control StudiesCohort StudiesCross-Over StudiesHumanscase-crossoverEpidemiology

Identifiers

PMID24756878
PMCPMC4190513

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.