Trial reportPsychological science2014
Methylphenidate blocks effort-induced depletion of regulatory control in healthy volunteers.
Trial report in Psychological science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect.Psychological science · 2021Pooled it
- Testing the ego-depletion effect in optimized conditions.PloS one · 2019Trial
- The (non-)replicability of regulatory resource depletion: A field report employing non-invasive brain stimulation.PloS one · 2017Trial
- Understanding the role of subpopulations and reliability in between-group studies.Behavior research methods · 2022Article
- The puzzling relationship between multi-laboratory replications and meta-analyses of the published literature.Royal Society open science · 2022Article
- Developing an open science 'mindset'.Health psychology and behavioral medicine · 2022Review
- Comparing meta-analyses and preregistered multiple-laboratory replication projects.Nature human behaviour · 2020Article
- Article
- Searching for the bottom of the ego well: failure to uncover ego depletion in Many Labs 3.Royal Society open science · 2018Article
- Self-reports from behind the scenes: Questionable research practices and rates of replication in ego depletion research.PloS one · 2018Article
- Understanding Performance Decrements in a Letter-Canceling Task: Overcoming Habits or Inhibition of Reading.Frontiers in psychology · 2018Article
- Commentary: "Misguided Effort with Elusive Implications" and "A Multi-Lab Pre-Registered Replication of the Ego Depletion Effect".Frontiers in psychology · 2017Article
- The Nature of Self-Regulatory Fatigue and "Ego Depletion": Lessons From Physical Fatigue.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2016Article
- How to Make Nothing Out of Something: Analyses of the Impact of Study Sampling and Statistical Interpretation in Misleading Meta-Analytic Conclusions.Frontiers in psychology · 2016Article
- Commentary: Misguided Effort with Elusive Implications, and Sifting Signal from Noise with Replication Science.Frontiers in psychology · 2016Article
- Six Questions for the Resource Model of Control (and Some Answers).Social and personality psychology compass · 2015Article
- Finding the self by losing the self: Neural correlates of ego-dissolution under psilocybin.Human brain mapping · 2015Article
- Neuroenhancement and the strength model of self-control.Frontiers in psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A recent wave of studies--more than 100 conducted over the last decade--has shown that exerting effort at controlling impulses or behavioral tendencies leaves a person depleted and less able to engage in subsequent rounds of regulation. Regulatory depletion is thought to play an important role in everyday problems (e.g., excessive spending, overeating) as well as psychiatric conditions, but its neurophysiological basis is poorly understood. Using a placebo-controlled, double-blind design, we demonstrated that the psychostimulant methylphenidate (commonly known as Ritalin), a catecholamine reuptake blocker that increases dopamine and norepinephrine at the synaptic cleft, fully blocks effort-induced depletion of regulatory control. Spectral analysis of trial-by-trial reaction times revealed specificity of methylphenidate effects on regulatory depletion in the slow-4 frequency band. This band is associated with the operation of resting-state brain networks that produce mind wandering, which raises potential connections between our results and recent brain-network-based models of control over attention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.