ReviewThe Journal of physiology2014
The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?
Review in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 130 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"
Molecular Pathways Involved in Knee Pain: an Observational Study
Who cites it
130 citing papers in PubMed, 2 syntheses or guidelines pooled it, 287 citations in OpenAlex.
- Pooled it
- Effect of probiotics and paraprobiotics on patients with sleep disorders and sub-healthy sleep conditions: a meta-analysis of randomized controlled trials.Frontiers in neurology · 2024Pooled it
- The Effect of Multiprobiotics on Memory and Attention in Fibromyalgia: A Pilot Randomized Controlled Trial.International journal of environmental research and public health · 2021Trial
- A Pilot Randomized Controlled Trial to Explore Cognitive and Emotional Effects of Probiotics in Fibromyalgia.Scientific reports · 2018Trial
- Glutamine supplementation reduces markers of intestinal permeability during running in the heat in a dose-dependent manner.European journal of applied physiology · 2017Trial
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- The Gut-Brain-Immune Axis: Role of Microbiota Dysbiosis and Autonomic Nervous System in Infectious Diseases.Cureus · 2026Review
- Mechanism of the protective effect of 2,3,5,4'-Tetrahydroxy stilbene-2-O-β-D-glucoside on MPTP-induced Parkinson's disease mice.Histology and histopathology · 2026Article
- Nutritional Management of Schizophrenia: Gut-Brain Axis Mechanisms and Dietary Interventions.Molecular neurobiology · 2026Review
- Proteomics Approaches for Discovering Novel Protein Biomarkers in Inflammatory Bowel Disease-Related Cancer.Biomolecules · 2025Review
- Formation of gut microbiota and application of microecological regulators in children.Translational pediatrics · 2025Review
- The interaction between rumen microbiota and neurotransmitters plays an important role in the adaptation of phenological changes in Tibetan sheep.BMC veterinary research · 2025Article
- Intimate partner violence and stress-related disorders: from epigenomics to resilience.Frontiers in global women's health · 2025Review
- Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors.Brain, behavior, and immunity · 2025Article
- Effects of Barefoot Walking in Urban Forests on CRP, IFNγ, and Serotonin Levels.Healthcare (Basel, Switzerland) · 2024Article
- Ex vivo and miniaturized in vitro3 Biotech · 2024Review
- Migraine is associated with the development of adult patients with inflammatory bowel disease: a nationwide, population-based study.Scientific reports · 2024Article
- Probiotics Show Promise as a Novel Natural Treatment for Neurological Disorders.Current pharmaceutical biotechnology · 2024Review
- Roles of the gut microbiota in human neurodevelopment and adult brain disorders.Frontiers in neuroscience · 2024Review
- Stress and the gut-brain axis: an inflammatory perspective.Frontiers in molecular neuroscience · 2024Review
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut-brain axis is the bidirectional communication between the gut and the brain, which occurs through multiple pathways that include hormonal, neural and immune mediators. The signals along this axis can originate in the gut, the brain or both, with the objective of maintaining normal gut function and appropriate behaviour. In recent years, the study of gut microbiota has become one of the most important areas in biomedical research. Attention has focused on the role of gut microbiota in determining normal gut physiology and immunity and, more recently, on its role as modulator of host behaviour ('microbiota-gut-brain axis'). We therefore review the literature on the role of gut microbiota in gut homeostasis and link it with mechanisms that could influence behaviour. We discuss the association of dysbiosis with disease, with particular focus on functional bowel disorders and their relationship to psychological stress. This is of particular interest because exposure to stressors has long been known to increase susceptibility to and severity of gastrointestinal diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.