Evidence map›Paper›PMID 24756343›Full record

ReviewCurrent diabetes reports2014

Environmental endocrine disruption of energy metabolism and cardiovascular risk.

Andrew G Kirkley, Robert M Sargis

Open access · greenAbstract readReview
In one paragraph

Review in Current diabetes reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive Aspects.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Andrew G KirkleyCommittee on Molecular Pathogenesis and Molecular Medicine, University of Chicago, Chicago, IL, USA.
Robert M Sargis
University of Chicago · US

Funding

TRANSGENIC COREP60DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI BELL, GRAEME I · 1985 to 2012
$25.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Matthew J Brady · 2013 to 2026
$20.9M
Environmental Endocrine Disruption of Adipocyte MetabolismK08ES019176 · NIEHS · UNIVERSITY OF CHICAGO · PI SARGIS, ROBERT M · 2010 to 2014
$797k
Metabolic Impact of Fetal or Adult Exposure to Environmental Endocrine DisruptorsR21ES021354 · NIEHS · UNIVERSITY OF CHICAGO · PI SARGIS, ROBERT M · 2013 to 2014
$432k
NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P60 DK020595NIDDK NIH HHS P60-DK020595NIEHS NIH HHS K08 ES019176NIEHS NIH HHS K08-ES019176NIEHS NIH HHS R21 ES021354NIEHS NIH HHS R21-ES021354
6 · The paper itself

Abstract

Rates of metabolic diseases have increased at an astounding rate in recent decades. Even though poor diet and physical inactivity are central drivers, these lifestyle changes alone fail to fully account for the magnitude and rapidity of the epidemic. Thus, attention has turned to identifying novel risk factors, including the contribution of environmental endocrine disrupting chemicals. Epidemiologic and preclinical data support a role for various contaminants in the pathogenesis of diabetes. In addition to the vascular risk associated with dysglycemia, emerging evidence implicates multiple pollutants in the pathogenesis of atherosclerosis and cardiovascular disease. Reviewed herein are studies linking endocrine disruptors to these key diseases that drive significant individual and societal morbidity and mortality. Identifying chemicals associated with metabolic and cardiovascular disease as well as their mechanisms of action is critical for developing novel treatment strategies and public policy to mitigate the impact of these diseases on human health.

Indexed as

AnimalsAtherosclerosisBenzhydryl CompoundsBisphenol A CompoundsEndocrine DisruptorsEnergy MetabolismEnvironmental ExposureEnvironmental PollutantsFemaleHumansMaleModels, AnimalObesityPhenolsPregnancyPrenatal Exposure Delayed EffectsBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsEnvironmental PollutantsPhenols

Identifiers

PMID24756343
PMCPMC4067479
OpenAlexW2050441553

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.