Evidence map›Paper›PMID 24756302›Full record

Trial reportJAMA neurology2014

The idiopathic intracranial hypertension treatment trial: clinical profile at baseline.

Michael Wall, Mark J Kupersmith, Karl D Kieburtz, James J Corbett, Steven E Feldon, Deborah I Friedman, David M Katz, John L Keltner, Eleanor B Schron, Michael P McDermott and 1 more

2 registry-linked trialsOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JAMA neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 173 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 3 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01003639 phase2 / phase3completednot on this map

A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss

TypeinterventionalSponsorSt. Luke's-Roosevelt Hospital CenterRan2010 to 2014Enrolled165ConditionsIdiopathic Intracranial HypertensionArmsAcetazolamide, Placebo, Formal weight loss counselling program
NCT04032379 recruitingnot on this mapstarted 2018, after this paper: background citation

Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension

Typeobservational_patient_registrySponsorDanish Headache CenterRan2018 to 2027Enrolled300ConditionsBenign Intracranial HypertensionArmsStandard treatment
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 3 syntheses or guidelines pooled it, 464 citations in OpenAlex.

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  16. How to diagnose papilloedema.Practical neurology · 2026
    Review
  17. Papilledema and related clinical and paraclinical visual assessment in cerebral venous and sinus thrombosis versus idiopathic intracranial hypertension.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
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  19. Clinical characteristics and outcomes of non-obese patients with idiopathic intracranial hypertension: a retrospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  20. Article

113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Michael WallDepartment of Neurology, University of Iowa, Iowa City2Department of Ophthalmology, University of Iowa, Iowa City.
Mark J KupersmithRoosevelt Hospital, New York, New York4New York Eye and Ear Infirmary, New York, New York.
Karl D KieburtzCenter for Human Experimental Therapeutics, University of Rochester, Rochester, New York.
James J CorbettDepartment of Neurology, University of Mississippi, Jackson7Department of Ophthalmology, University of Mississippi, Jackson.
Steven E FeldonDepartment of Ophthalmology, University of Rochester, Rochester, New York.
Deborah I FriedmanDepartment of Neurotherapeutics and Ophthalmology, University of Texas Southwestern Medical Center, Dallas10Department of Neurology, University of Texas Southwestern Medical Center, Dallas.
David M KatzBethesda Neurology, Bethesda, Maryland.
John L KeltnerDepartment of Ophthalmology, University of California-Davis.
Eleanor B SchronDivision of Extramural Research, National Eye Institute, Bethesda, Maryland.
Michael P McDermottCenter for Human Experimental Therapeutics, University of Rochester, Rochester, New York14Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York.
NORDIC Idiopathic Intracranial Hypertension Study Group
University of Rochester · USMaryland Oncology Hematology · USNational Eye Institute · USNew York Eye and Ear Infirmary · USThe University of Texas Southwestern Medical Center · USUniversity of California, Davis · USUniversity of Iowa · USUniversity of Mississippi · US

Funding

Neuro-Ophthalmology Research Disease Investigator Consortium (NORDIC) NetworkU10EY017281 · NEI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI KUPERSMITH, MARK J · 2009 to 2014
$10.2M
Data Coordination and Biostatistics Center for the NORDIC NetworkU10EY017387 · NEI · UNIVERSITY OF ROCHESTER · PI KIEBURTZ, KARL D. · 2009 to 2013
$7.0M
NEI NIH HHS 1U10EY017281-01A1NEI NIH HHS 1U10EY017387-01A1NEI NIH HHS 1U10EY017387-01A1S1NEI NIH HHS 3U10EY017281-01A1S1NEI NIH HHS 3U10EY017281-01A1S2NEI NIH HHS U10 EY017281NEI NIH HHS U10 EY017387
6 · The paper itself

Abstract

importanceTo our knowledge, there are no large prospective cohorts of untreated patients with idiopathic intracranial hypertension (IIH) to characterize the disease.

objectiveTo report the baseline clinical and laboratory features of patients enrolled in the Idiopathic Intracranial Hypertension Treatment Trial. DESIGN, SETTING, AND

participantsWe collected data at baseline from questionnaires, examinations, automated perimetry, and fundus photography grading. Patients (n = 165) were enrolled from March 17, 2010, to November 27, 2012, at 38 academic and private practice sites in North America. All participants met the modified Dandy criteria for IIH and had a perimetric mean deviation between -2 dB and -7 dB. All but 4 participants were women. MAIN OUTCOMES AND MEASURES: Baseline and laboratory characteristics.

resultsThe mean (SD) age of our patients was 29.0 (7.4) years and 4 (2.4%) were men. The average (SD) body mass index (calculated as weight in kilograms divided by height in meters squared) was 39.9 (8.3). Headache was the most common symptom (84%). Transient visual obscurations occurred in 68% of patients, back pain in 53%, and pulse synchronous tinnitus in 52%. Only 32% reported visual loss. The average (SD) perimetric mean deviation in the worst eye was -3.5 (1.1) dB, (range, -2.0 to -6.4 dB) and in the best eye was -2.3 (1.1) dB (range, -5.2 to 0.8 dB). A partial arcuate visual field defect with an enlarged blind spot was the most common perimetric finding. Visual acuity was 85 letters or better (20/20) in 71% of the worst eyes and 77% of the best eyes. Quality of life measures, including the National Eye Institute Visual Function Questionnaire-25 and the Short Form-36 physical and mental health summary scales, were lower compared with population norms. CONCLUSIONS AND RELEVANCE: The Idiopathic Intracranial Hypertension Treatment Trial represents the largest prospectively analyzed cohort of untreated patients with IIH. Our data show that IIH is almost exclusively a disease of obese young women. Patients with IIH with mild visual loss have typical symptoms, may have mild acuity loss, and have visual field defects, with predominantly arcuate loss and enlarged blind spots that require formal perimetry for detection.

trial registrationclinicaltrials.gov Identifier: NCT01003639.

Indexed as

AdolescentAdultCohort StudiesFemaleHumansIntracranial HypertensionMaleMiddle AgedProspective StudiesSex FactorsSurveys and QuestionnairesVision DisordersVisual AcuityYoung Adult

Identifiers

PMID24756302
PMCPMC4351808
OpenAlexW2011664591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.