ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2014
The Ph-3 gene from Solanum pimpinellifolium encodes CC-NBS-LRR protein conferring resistance to Phytophthora infestans.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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56 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Unraveling the genetic basis of quantitative resistance to diseases in tomato: a meta-QTL analysis and mining of transcript profiles.Plant cell reports · 2024Pooled it
- Advances in genomics-driven genetic decoding and genomic design breeding in tomato.Horticulture research · 2026Article
- Late blight resistance of Julius Kühn Institute pre-breeding potato clones: a genome-wide association study.BMC plant biology · 2026Article
- Genome-wide association analysis and linkage mapping decipher the genetic control of primary metabolites and quality traits in Capsicum.The Plant journal : for cell and molecular biology · 2025Article
- Multiplex PCR for Early Generation Identification of Tomato Segregants Carrying Ty-2, Ty-3 and Ph-3 Resistance Alleles Against Leaf Curl and Late Blight Diseases.Molecular biotechnology · 2025Article
- Identification of late blight resistance QTLsMolecular breeding : new strategies in plant improvement · 2025Article
- Molecular breeding of tomato: Advances and challenges.Journal of integrative plant biology · 2025Review
- Identification and Functional Analysis of thePlants (Basel, Switzerland) · 2024Article
- Identification and mapping of late blight resistance QTLs in the wild tomato accession PI 224710 (Molecular breeding : new strategies in plant improvement · 2024Article
- Chromosome-level genome assembly of Solanum pimpinellifolium.Scientific data · 2024Article
- Article
- Identification and mapping of QTLs for late blight resistance in the wild tomato (Frontiers in plant science · 2024Article
- Marker assisted early generation identification of root knot disease resistant orange tomato segregants with multiple desirable alleles.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Integrated Molecular and Bioinformatics Approaches for Disease-Related Genes in Plants.Plants (Basel, Switzerland) · 2023Review
- Transcriptome-Assisted SNP Marker Discovery forInternational journal of molecular sciences · 2023Article
- Vegetable biology and breeding in the genomics era.Science China. Life sciences · 2023Review
- A physical map of traits of agronomic importance based on potato and tomato genome sequences.Frontiers in genetics · 2023Review
- Marker assisted stacking ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2023Article
- Identification of late blight resistance quantitative trait loci in Solanum pimpinellifolium accession PI 270441.The plant genome · 2022Article
- Comparative transcriptomic responses of European and Japanese larches to infection by Phytophthora ramorum.BMC plant biology · 2022Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messagePh-3 is the first cloned tomato gene for resistance to late blight and encodes a CC-NBS-LRR protein. Late blight, caused by Phytophthora infestans, is one of the most destructive diseases in tomato. The resistance (R) gene Ph-3, derived from Solanum pimpinellifolium L3708, provides resistance to multiple P. infestans isolates and has been widely used in tomato breeding programmes. In our previous study, Ph-3 was mapped into a region harbouring R gene analogues (RGA) at the distal part of long arm of chromosome 9. To further narrow down the Ph-3 interval, more recombinants were identified using the flanking markers G2-4 and M8-2, which defined the Ph-3 gene to a 26 kb region according to the Heinz1706 reference genome. To clone the Ph-3 gene, a bacterial artificial chromosome (BAC) library was constructed using L3708 and one BAC clone B25E21 containing the Ph-3 region was identified. The sequence of the BAC clone B25E21 showed that only one RGA was present in the target region. A subsequent complementation analysis demonstrated that this RGA, encoding a CC-NBS-LRR protein, was able to complement the susceptible phenotype in cultivar Moneymaker. Thus this RGA was considered the Ph-3 gene. The predicted Ph-3 protein shares high amino acid identity with the chromosome-9-derived potato resistance proteins against P. infestans (Rpi proteins).
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