Evidence map›Paper›PMID 24756225›Full record

ArticleThe Analyst2014

Microfluidic-SERS devices for one shot limit-of-detection.

Donghyuk Kim, Antonio R Campos, Ashish Datt, Zhe Gao, Matthew Rycenga, Nathan D Burrows, Nathan G Greeneltch, Chad A Mirkin, Catherine J Murphy, Richard P Van Duyne and 1 more

Abstract read
In one paragraph

Article in The Analyst, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Donghyuk Kim *Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455 U.S.A.
Antonio R Campos *Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455 U.S.A.
Ashish DattDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455 U.S.A.
Zhe GaoDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455 U.S.A.
Matthew RycengaDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, Illinois 60208 U.S.A.
Nathan D BurrowsDepartment of Chemistry, University of Illinois at Urbana-Champaign, 505 S Mathews Avenue, Urbana, Illinois 61801 U.S.A.
Nathan G GreeneltchDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, Illinois 60208 U.S.A.
Chad A MirkinDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, Illinois 60208 U.S.A.
Catherine J MurphyDepartment of Chemistry, University of Illinois at Urbana-Champaign, 505 S Mathews Avenue, Urbana, Illinois 61801 U.S.A.
Richard P Van DuyneDepartment of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, Illinois 60208 U.S.A.
Christy L HaynesDepartment of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455 U.S.A.

Funding

IMMUNE SYSTEM-ON-A-CHIP FOR QUANTITATIVE ANALYSIS OF CELL INTERACTIONS DURING ALLDP2OD004258 · OD · UNIVERSITY OF MINNESOTA · PI HAYNES, CHRISTY L · 2008 to 2008
$2.3M
NIH HHS DP2 OD004258NIH HHS DP2 OD004258-01
6 · The paper itself

Abstract

Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.

Indexed as

Equipment DesignGoldMicrofluidic Analytical TechniquesMicroscopy, FluorescenceNanostructuresOptical ImagingSpectrum Analysis, RamanGold

Identifiers

PMID24756225
PMCPMC4067008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.