ArticleThe Journal of investigative dermatology2014
Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice.
Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Can invariant Natural Killer T cells drive B cell fate? a look at the humoral response.Frontiers in immunology · 2025Review
- MR1 deficiency enhances IL-17-mediated allergic contact dermatitis.Frontiers in immunology · 2023Article
- Topical Application of Metal Allergens Induces Changes to Lipid Composition of Human Skin.Frontiers in toxicology · 2022Article
- Contact dermatitis.Nature reviews. Disease primers · 2021Review
- Skin-resident natural killer T cells participate in cutaneous allergic inflammation in atopic dermatitis.The Journal of allergy and clinical immunology · 2021Article
- Lysophosphatidylcholine aggravates contact hypersensitivity by promoting neutrophil infiltration and IL17 expression.BMB reports · 2021Article
- The role of invariant T cells in inflammation of the skin and airways.Seminars in immunopathology · 2019Review
- Topical anti-inflammatory and anti-oxidative effects of porcine placenta extracts on 2,4-dinitrochlorobenzene-induced contact dermatitis.BMC complementary and alternative medicine · 2018Article
- Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy.PloS one · 2018Article
- A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease.Scientific reports · 2017Article
- Contact sensitizers trigger human CD1-autoreactive T-cell responses.European journal of immunology · 2017Article
- Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy.International journal of molecular sciences · 2017Article
- Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis.International journal of molecular sciences · 2016Review
- Novel concept of iSALT (inducible skin-associated lymphoid tissue) in the elicitation of allergic contact dermatitis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2016Review
- Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.Scientific reports · 2015Article
- Re: natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice.The Journal of investigative dermatology · 2015Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contact hypersensitivity (CHS) has been widely used to study cutaneous immune responses, as a prototype of delayed-type hypersensitivity. Although natural killer T (NKT) cells have been assumed to have an important role in CHS, their role is controversial. Here, we report the role of NKT cells in the sensitization phase of CHS, by promoting the survival and maturation of dendritic cells (DCs) in the draining lymph nodes (LNs). The CHS response was attenuated with Cd1d1(-/-) and Traj18(-/-) BALB/c mice in which NKT cells were absent. In the draining LNs, the number of effector T cells and cytokine production were significantly reduced with NKT cell-deficient mice. NKT cells activated and colocalized with DCs in the draining LNs after sensitization. The number of migrated and mature DCs was reduced in NKT cell-deficient mice 72 hours after FITC application. In in vitro experiments, activated NKT cells enhanced bone marrow-derived DC (BMDC) survivability via tumor necrosis factor (TNF) production from BMDCs. In addition, TNF production from BMDCs was partially suppressed by the neutralizing anti-CD54 or CD154 antibodies. Our data demonstrate that DC-NKT interaction has a pivotal role in the sensitization phase of CHS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.