ArticlePloS one2014
Association of veterinary third-generation cephalosporin use with the risk of emergence of extended-spectrum-cephalosporin resistance in Escherichia coli from dairy cattle in Japan.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Prevalence of extended-spectrum β-lactamase and carbapenemase-producing Escherichia coli from patients, cattle, and environmental sources in northwest Amhara, Ethiopia: a one health approach.BMC microbiology · 2026Article
- Article
- Antimicrobial resistance and prevalence of extended-spectrum beta-lactamase-producingMicrobiology spectrum · 2024Article
- Characterization of Escherichia coli and Other Enterobacterales Resistant to Extended-Spectrum Cephalosporins Isolated from Dairy Manure in Ontario, Canada.Applied and environmental microbiology · 2023Article
- Prevalence and antimicrobial resistance profiles of extended-spectrum beta-lactamase-producingFrontiers in veterinary science · 2023Article
- Incidence and Treatments of Bovine Mastitis and Other Diseases on 37 Dairy Farms in Wisconsin.Pathogens (Basel, Switzerland) · 2022Article
- Realities, Challenges and Benefits of Antimicrobial Stewardship in Dairy Practice in the United States.Microorganisms · 2022Review
- Phenotypic and genotypic characterization of antimicrobial resistance profiles inFrontiers in microbiology · 2022Article
- The epidemiology of AmpC-producingJournal of medical microbiology · 2021Article
- Canadian Dairy Network for Antimicrobial Stewardship and Resistance (CaDNetASR): An On-Farm Surveillance System.Frontiers in veterinary science · 2021Article
- Shared Extended-Spectrum β-Lactamase-ProducingMicroorganisms · 2020Article
- Spread of Antimicrobial Resistance byAntibiotics (Basel, Switzerland) · 2020Article
- Antimicrobial resistance at the human-animal interface in the Pastoralist Communities of Kasese District, South Western Uganda.Scientific reports · 2020Article
- Extended-spectrum β-lactamase-producingJournal of equine science · 2019Article
- Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and vanA genes.The Journal of antibiotics · 2019Article
- Characteristics ofBioMed research international · 2018Article
- Prevalence and Characterization of Multi-Drug-Resistant Gram-Negative Bacilli Isolated From Lebanese Poultry: A Nationwide Study.Frontiers in microbiology · 2018Article
- Characterization of Resistance Patterns and Detection of Apramycin Resistance Genes inFrontiers in microbiology · 2018Article
- Recent Emergence of Escherichia coli with Cephalosporin Resistance Conferred by blaCTX-M on Washington State Dairy Farms.Applied and environmental microbiology · 2015Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of extended-spectrum cephalosporins in food animals has been suggested to increase the risk of spread of Enterobacteriaceae carrying extended-spectrum β-lactamases to humans. However, evidence that selection of extended-spectrum cephalosporin-resistant bacteria owing to the actual veterinary use of these drugs according to criteria established in cattle has not been demonstrated. In this study, we investigated the natural occurrence of cephalosporin-resistant Escherichia coli in dairy cattle following clinical application of ceftiofur. E. coli isolates were obtained from rectal samples of treated and untreated cattle (n = 20/group) cultured on deoxycholate-hydrogen sulfide-lactose agar in the presence or absence of ceftiofur. Eleven cefazoline-resistant isolates were obtained from two of the ceftiofur-treated cattle; no cefazoline-resistant isolates were found in untreated cattle. The cefazoline-resistant isolates had mutations in the chromosomal ampC promoter region and remained susceptible to ceftiofur. Eighteen extended-spectrum cephalosporin-resistant isolates from two ceftiofur-treated cows were obtained on ceftiofur-supplemented agar; no extended-spectrum cephalosporin-resistant isolates were obtained from untreated cattle. These extended-spectrum cephalosporin-resistant isolates possessed plasmid-mediated β-lactamase genes, including bla(CTX-M-2) (9 isolates), bla(CTX-M-14) (8 isolates), or bla(CMY-2) (1 isolate); isolates possessing bla(CTX-M-2) and bla(CTX-M-14) were clonally related. These genes were located on self-transmissible plasmids. Our results suggest that appropriate veterinary use of ceftiofur did not trigger growth extended-spectrum cephalosporin-resistant E. coli in the bovine rectal flora; however, ceftiofur selection in vitro suggested that additional ceftiofur exposure enhanced selection for specific extended-spectrum cephalosporin-resistant β-lactamase-expressing E. coli clones.
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