ReviewNature reviews. Cardiology2014
Comprehensive plaque assessment by coronary CT angiography.
Review in Nature reviews. Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 191 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
National Plaque Registry and Database
Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II (EMERALD II) Study
Who cites it
191 citing papers in PubMed, 2 syntheses or guidelines pooled it, 369 citations in OpenAlex.
- Noninvasive fractional flow reserve derived from coronary computed tomography angiography for identification of ischemic lesions: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Standards for quantitative assessments by coronary computed tomography angiography (CCTA): An expert consensus document of the society of cardiovascular computed tomography (SCCT).Journal of cardiovascular computed tomographyGuideline
- Coronary Plaque Radiomic Phenotypes Predict Fatal or Nonfatal Myocardial Infarction: Analysis of the SCOT-HEART Trial.JACC. Cardiovascular imaging · 2025Trial
- Combined prognostic value of AI-derived CT-FFR and high-risk plaque characteristics in patients with newly diagnosed chronic coronary syndrome: a prospective cohort study.Frontiers in cardiovascular medicine · 2025Trial
- Prediction of acute coronary syndrome within 3 years using radiomics signature of pericoronary adipose tissue based on coronary computed tomography angiography.European radiology · 2022Trial
- Trial
- Quantitative coronary plaque analysis predicts high-risk plaque morphology on coronary computed tomography angiography: results from the ROMICAT II trial.The international journal of cardiovascular imaging · 2018Trial
- Serum oxidized low-density lipoprotein decreases in response to statin therapy and relates independently to reductions in coronary plaque in patients with HIV.AIDS (London, England) · 2016Trial
- Computed tomography-based high-risk coronary plaque score to predict acute coronary syndrome among patients with acute chest pain--Results from the ROMICAT II trial.Journal of cardiovascular computed tomographyTrial
- Advanced quantitative CT for coronary artery disease: integrating stenosis quantification, plaque quantification, and fractional flow reserve-CT.The British journal of radiology · 2026Review
- Quantification of plaque and detection of high-risk plaque characteristics based on coronary computed tomography angiography: comparison between superresolution deep learning reconstruction and hybrid iterative reconstruction.Quantitative imaging in medicine and surgery · 2026Article
- Role of T1-weighted MRI in Identifying Coronary Intraplaque Hemorrhage: CATCH the Truly High-Risk Plaque.Journal of atherosclerosis and thrombosis · 2026Review
- Role of artificial intelligence in developing predictive models for major adverse cardiovascular outcomes using CCTA adipose tissue characteristics: a systematic review and meta-analysis.European heart journal. Digital health · 2026Review
- Explainable ML for ACS culprit plaques: a multidimensional CCTA model highlighting hemodynamic increment.The international journal of cardiovascular imaging · 2026Article
- Subclinical Inflammation in Ischemic Heart Disease and Its Role in the Transition to Heart Failure.Life (Basel, Switzerland) · 2026Review
- Non-invasive assessment of plaque characteristics in diffuse and focal coronary artery disease; plaque vulnerability and high-risk features.The international journal of cardiovascular imaging · 2026Article
- Coronary Atherosclerosis in Master Athletes: Current Knowledge and Future Challenges.Journal of personalized medicine · 2026Review
- Immune Checkpoint Inhibitor Therapy and Acute Coronary Syndrome: A Review of Mechanisms and Management.Journal of the American Heart Association · 2026Review
- Relationship Between Perivascular Fat Inflammation and Coronary Atherosclerotic Plaque Composition.Journal of clinical medicine · 2026Article
- Association between subclinical coronary artery atherosclerosis and oral health-a study on a Swedish population.BDJ open · 2026Article
131 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most acute coronary syndromes are caused by sudden luminal thrombosis due to atherosclerotic plaque rupture or erosion. Preventing such an event seems to be the only effective strategy to reduce mortality and morbidity of coronary heart disease. Coronary lesions prone to rupture have a distinct morphology compared with stable plaques, and provide a unique opportunity for noninvasive imaging to identify vulnerable plaques before they lead to clinical events. The submillimeter spatial resolution and excellent image quality of modern computed tomography (CT) scanners allow coronary atherosclerotic lesions to be detected, characterized, and quantified. Large plaque volume, low CT attenuation, napkin-ring sign, positive remodelling, and spotty calcification are all associated with a high risk of acute cardiovascular events in patients. Computation fluid dynamics allow the calculation of lesion-specific endothelial shear stress and fractional flow reserve, which add functional information to plaque assessment using CT. The combination of morphologic and functional characteristics of coronary plaques might enable noninvasive detection of vulnerable plaques in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.