ArticlePloS one2014
Transcriptomic and functional analysis of NaCl-induced stress in Enterococcus faecalis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Functional redundancy of translation-associated factors masks the role of YebC2 in Enterococcus faecalis.Folia microbiologica · 2026Article
- Dissecting the contribution of Kup and KimA to Enterococcus faecalis potassium homeostasis.Scientific reports · 2025Article
- Beyond Harmful: Exploring Biofilm Formation by Enterococci Isolated from Portuguese Traditional Cheeses.Foods (Basel, Switzerland) · 2024Article
- Enterococcus faecalis: implications for host health.World journal of microbiology & biotechnology · 2024Review
- The two-component system CroRS acts as a master regulator of cell envelope homeostasis to confer antimicrobial tolerance in the bacterial pathogen Enterococcus faecalis.Molecular microbiology · 2023Article
- Redundant potassium transporter systems guarantee the survival ofFrontiers in microbiology · 2023Article
- Identification of novel salt tolerance-associated proteins from the secretome of Enterococcus faecalis.World journal of microbiology & biotechnology · 2022Article
- RNA-Seq Transcriptomic Analysis of Green Tea Polyphenols Modulation of Differently Expressed Genes in Enterococcus faecalis Under Bile Salt Stress.Current microbiology · 2022Article
- Metatranscriptome sequencing identifiesFrontiers in microbiology · 2022Article
- Sugarcoating it: Enterococcal polysaccharides as key modulators of host-pathogen interactions.PLoS pathogens · 2021Review
- Effects of Osmotic Stress and Sodium Hypochlorite on Endodontic Microbiota: An In-Vitro Study.European endodontic journal · 2020Article
- Using Selection by Nonantibiotic Stressors to Sensitize Bacteria to Antibiotics.Molecular biology and evolution · 2020Article
- Article
- Article
- Persistence and Decay of Fecal Microbiota in Aquatic Habitats.Microbiology and molecular biology reviews : MMBR · 2019Review
- Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.Microbiology and molecular biology reviews : MMBR · 2019Review
- Decoding the proteomic changes involved in the biofilm formation of Enterococcus faecalis SK460 to elucidate potential biofilm determinants.BMC microbiology · 2019Article
- Extended persistence of general and cattle-associated fecal indicators in marine and freshwater environment.The Science of the total environment · 2019Article
- Biogenic Amine Production by Lactic Acid Bacteria: A Review.Foods (Basel, Switzerland) · 2019Review
- Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype.Cell reports · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The robust physiology of Enterococcus faecalis facilitates tolerance to various stresses. We here report the transcriptional response of E. faecalis V583 to growth in the presence of 6.5% NaCl. Among the early responses observed was an immediate down-regulation of mscL, accompanied by an up-regulation of genes predicted to be involved in uptake of extracellular potassium and glycine betaine. The high NaCl concentration also induced expression of chaperons and cell envelope related traits, such as the enterococcal polysaccharide antigen (epa) locus. Functional genetic analysis revealed reduced salt stress resistance in both epaB and epaE mutants. The reduced salt resistance phenotype associated with the epaB mutant was restored by complementation, hence demonstrating a role of Epa in the physiological robustness of E. faecalis. Furthermore, we demonstrate that Epa confers increased resistance towards multiple cell envelope stress-inducing factors. Accordingly, these findings delineate a potential link between the robust nature of E. faecalis and its ability to perform as a human pathogen, and provide a new perspective on the mechanisms by which Epa contributes to virulence. Notably, the high NaCl concentration also resulted in strict repression of the gelE-sprE operon and impaired gelatinase activity. We demonstrate that NaCl antagonize the GBAP-pheromone dependent induction in a concentration dependent manner.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.