ArticleScientific reports2014
A method for estimating intracellular sodium concentration and extracellular volume fraction in brain in vivo using sodium magnetic resonance imaging.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 119 citations in OpenAlex.
- Triple-PulseMagnetic resonance in medicine · 2026Article
- pH-mediated activation of the lysosomal arginine sensor SLC38A9.FEBS letters · 2026Article
- Evaluation of Partial Volume Correction Techniques for Sodium MRI of the Achilles Tendon.Magnetic resonance in medicine · 2026Article
- High spatial resolutionbioRxiv : the preprint server for biology · 2026Article
- The effect of clinically relevant changes in extracellular electrolyte concentrations on human atrial arrhythmias.Communications medicine · 2025Article
- Functional and Structural Analyses of Diverse G-Quadruplex and Non-G-Quadruplex Structures Formed by Guanine-Rich Nucleic Acids: A Study on the Insulin Aptamer.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Polyacrylamide Gel Calibration Phantoms for Quantification in Sodium MRI.NMR in biomedicine · 2025Article
- Association between serum sodium and sporadic Parkinson's disease.Frontiers in neuroscience · 2025Article
- Modulation and distribution of extracellular free water and tract deficits in rhesus macaques before and after the initiation of emtricitabine + tenofovir disoproxil fumarate + dotutegravir treatment.Frontiers in immunology · 2025Article
- Relationship between sodium and diffusion MRI metrics in multiple sclerosis.Brain communications · 2025Article
- Article
- Hyperchloremia and Hypernatremia Decreased Microglial and Neuronal Survival during Oxygen-Glucose Deprivation/Reperfusion.Biomedicines · 2024Article
- A new approach to characterize cardiac sodium storage by combining fluorescence photometry and magnetic resonance imaging in small animal research.Scientific reports · 2024Article
- The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.Brain communications · 2024Review
- Sodium channels and the ionic microenvironment of breast tumours.The Journal of physiology · 2023Article
- Evaluation of Sodium Relaxation Times and Concentrations in the Achilles Tendon Using MRI.International journal of molecular sciences · 2022Article
- Quantitative Sodium (Diagnostics (Basel, Switzerland) · 2022Article
- Sodium MRI at 7T for Early Response Evaluation of Intracranial Tumors following Stereotactic Radiotherapy Using the CyberKnife.AJNR. American journal of neuroradiology · 2022Article
- Sodium MR Neuroimaging.AJNR. American journal of neuroradiology · 2021Review
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In this feasibility study we propose a method based on sodium magnetic resonance imaging (MRI) for estimating simultaneously the intracellular sodium concentration (C1, in mM) and the extracellular volume fraction (α) in grey and white matters (GM, WM) in brain in vivo. Mean C1 over five healthy volunteers was measured ~11 mM in both GM and WM, mean α was measured ~0.22 in GM and ~0.18 in WM, which are in close agreement with standard values for healthy brain tissue (C1 ~ 10-15 mM, α ~ 0.2). Simulation of 'fluid' and 'solid' inclusions were accurately detected on both the C1 and α 3D maps and in the C1 and α distributions over whole GM and WM. This non-invasive and quantitative method could provide new biochemical information for assessing ion homeostasis and cell integrity in brain and help the diagnosis of early signs of neuropathologies such as multiple sclerosis, Alzheimer's disease, brain tumors or stroke.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.