ArticlePloS one2014
Quinolone resistance mechanisms among extended-spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from rivers and lakes in Switzerland.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 68 citations in OpenAlex.
- CharacterizingAntibiotics (Basel, Switzerland) · 2026Article
- Plasmid-Mediated Quinolone Resistance Genes inVeterinary sciences · 2026Article
- Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence.BMC infectious diseases · 2025Article
- Tracking Extended-Spectrum Beta Lactamase-ProducingOpen forum infectious diseases · 2025Article
- Whole genome sequence analysis reveals high genomic diversity and potential host-driven adaptations among multidrug-resistantFrontiers in microbiology · 2024Article
- Prevalence and mechanisms of ciprofloxacin resistance in Escherichia coli isolated from hospitalized patients, healthy carriers, and wastewaters in Iran.BMC microbiology · 2023Article
- QUIRMIA-A Phenotype-Based Algorithm for the Inference of Quinolone Resistance Mechanisms inAntibiotics (Basel, Switzerland) · 2023Article
- Aquatic Environments as Hotspots of Transferable Low-Level Quinolone Resistance and Their Potential Contribution to High-Level Quinolone Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Twelve-year trend of Escherichia coli antibiotic resistance in the Islamabad population.Annals of medicine and surgery (2012) · 2022Article
- Genetic Comparison of ESBL-ProducingAntibiotics (Basel, Switzerland) · 2021Article
- Occurrence of Extended Spectrum Beta Lactamase (ESBL) Producers, Quinolone and Carbapenem ResistantInternational journal of environmental research and public health · 2021Article
- Multidrug-Resistant, Including Extended-Spectrum Beta Lactamase-Producing and Quinolone-Resistant,Antibiotics (Basel, Switzerland) · 2021Article
- High prevalence of plasmid-mediated quinolone resistance (PMQR) among E. coli from aquatic environments in Bangladesh.PloS one · 2021Article
- Plasmid-Mediated Ampicillin, Quinolone, and Heavy Metal Co-Resistance among ESBL-Producing Isolates from the Yamuna River, New Delhi, India.Antibiotics (Basel, Switzerland) · 2020Article
- Article
- Phenotypic and genotypic characteristics ofPorcine health management · 2019Article
- Tracing back multidrug-resistant bacteria in fresh herb production: from chive to source through the irrigation water chain.FEMS microbiology ecology · 2018Article
- The Prevalence of Colistin Resistant Strains and Antibiotic Resistance Gene Profiles in Funan River, China.Frontiers in microbiology · 2018Article
- High Prevalence of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Among Clinical Isolates From Cats and Dogs Admitted to a Veterinary Hospital in Switzerland.Frontiers in veterinary science · 2018Article
- Mechanisms of quinolone resistance inJournal of veterinary science · 2017Article
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5 authors at 1 institution in 1 country.
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Abstract
Sixty extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolated from rivers and lakes in Switzerland were screened for individual strains additionally exhibiting a reduced quinolone susceptibility phenotype. Totally, 42 such isolates were found and further characterized for their molecular (fluoro)quinolone resistance mechanisms. PCR and sequence analysis were performed to identify chromosomal mutations in the quinolone resistance-determining regions (QRDR) of gyrA, gyrB, parC and parE and to describe the occurrence of the following plasmid-mediated quinolone resistance genes: qepA, aac-6'-Ib-cr, qnrA, qnrB, qnrC, qnrD and qnrS. The contribution of efflux pumps to the resistance phenotype of selected strains was further determined by the broth microdilution method in the presence and absence of the efflux pump inhibitor phe-arg-β-naphthylamide (PAβN). Almost all strains, except two isolates, showed at least one mutation in the QRDR of gyrA. Ten strains showed only one mutation in gyrA, whereas thirty isolates exhibited up to four mutations in the QRDR of gyrA, parC and/or parE. No mutations were detected in gyrB. Most frequently the amino-acid substitution Ser83→Leu was detected in GyrA followed by Asp87→Asn in GyrA, Ser80→Ile in ParC, Glu84→Val in ParC and Ser458→Ala in ParE. Plasmid-mediated quinolone resistance mechanisms were found in twenty isolates bearing QnrS1 (4/20), AAC-6'-Ib-cr (15/20) and QepA (1/20) determinants, respectively. No qnrA, qnrB, qnrC and qnrD were found. In the presence of PAβN, the MICs of nalidixic acid were decreased 4- to 32-fold. (Fluoro) quinolone resistance is due to various mechanisms frequently associated with ESBL-production in E. coli from surface waters in Switzerland.
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