Evidence map›Paper›PMID 24755719›Full record

ArticleThe journal of ECT2014

Searching for the mechanism(s) of ECT's therapeutic effect.

W Vaughn McCall, Chittaranjan Andrade, Pascal Sienaert

Registry-linked trialAbstract read
In one paragraph

Article in The journal of ECT, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07527234 ("Conducting a Turkish Validity and Reliability Study of the Electroconvulsive Therapy Cognitive Assessment), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07527234 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

"Conducting a Turkish Validity and Reliability Study of the Electroconvulsive Therapy Cognitive Assessment (ECCA) and Comparing it With Other Cognitive Function Assessment Tests."

Typeobservational_patient_registrySponsorPamukkale UniversityRan2025 to 2026Enrolled90ConditionsElectroconvulsive Therapy (ECT), Electroconvulsive Therapy Cognitive Assessment (ECCA), Montreal Cognitive Assessment (MoCA), Turkish AdaptationArmsElectroConvulsive Therapy Cognitive Assessment (ECCA)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. How Neuroscience Is Informing Treatments: Ethical Issues.Focus (American Psychiatric Publishing) · 2019
    Article
  6. Bringing Neuroscience to the Bedside.Focus (American Psychiatric Publishing) · 2019
    Article
  7. Article
  8. Review
  9. [Depression in old age, part 2 : Comorbidity and treatment].Zeitschrift fur Gerontologie und Geriatrie · 2016
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

W Vaughn McCallFrom the *Department of Psychiatry and Health Behavior, The Medical College of Georgia; Georgia Regents University; Augusta, GA; †Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore, India and ‡Department of Mood Disorders and Department of ECT, University Psychiatric Center, Catholic University Leuven, Campus Kortenberg, Belgium.
Chittaranjan Andrade
Pascal Sienaert

Funding

7/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086127 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCCALL, WILLIAM VAUGHN · 2009 to 2013
$1.1M
NIMH NIH HHS U01 MH086127
6 · The paper itself

Abstract

The exact therapeutic mechanism of action of electroconvulsive therapy (ECT) remains unresolved. Numerous psychological theories from decades ago have been proven untrue. In the ensuing years, ECT has been proven to have numerous reproducible effects on brain chemistry, regional brain activity, electroencephalographic sleep stages, and neurogenesis. Clinically, ECT has been shown to have antidepressant, antipsychotic, antimanic, antiparkinsonian, and anticonvulsive effects. It is possible that different biological effects of ECT are responsible for different clinical effects or that several biological effects in concert work together to produce a given clinical effect. This paper comments on the array of possible mechanisms and points toward the future of mechanistic research in ECT.

Indexed as

AnimalsElectroconvulsive TherapyHumansMental Disorders

Identifiers

PMID24755719
PMCPMC4695970

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.