Evidence map›Paper›PMID 24755685›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2014

The diagnostic importance of matrix metalloproteinase-7 and nestin in gastrointestinal stromal tumors.

Kemal Peker, Ilyas Sayar, Ibrahim Gelincik, Gülay Bulut, Tuba Dilay Kökenek Ünal, Serkan Şenol, Aysun Gökçe, Arda Isik

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  6. Effects of siRNA-Mediated Knockdown of HDAC1 on the Biological Behavior of Esophageal Carcinoma Cell Lines.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
  7. Activity of MMP1 and MMP13 and amino acid metabolism in patients with alcoholic liver cirrhosis.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kemal PekerDepartment of General Surgery, Erzincan University, Erzincan, Turkey.
Ilyas SayarDepartment of Pathology, Erzincan University, Erzincan, Turkey.
Ibrahim GelincikDepartment of Pathology, Namik Kemal University, Tekirdag, Turkey.
Gülay BulutDepartment of Pathology, Yüzüncü Yil University, Van, Turkey.
Tuba Dilay Kökenek ÜnalDepartment of Pathology, Kayseri Training Research Hospital, Kayseri, Turkey.
Serkan ŞenolDepartment of Pathology, Medeniyet University, İstanbul, Turkey.
Aysun GökçeDepartment of Pathology, Dişkapi Training Research Hospital, Ankara, Turkey.
Arda IsikDepartment of General Surgery, Erzincan University, Erzincan, Turkey.
Erzincan Binali Yıldırım University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe importance of the matrix metalloproteinase-7 (MMP-7) and nestin immunomarkers, C-kit proto-oncogene (CD117), and the efficiency of the Ki-67 proliferation index for gastrointestinal stromal tumors were evaluated. MATERIAL AND

methodsThis study was conducted by examining the microscope slides of 72 patients with gastrointestinal stromal tumors that were sent to the pathology laboratory between 2007 and 2012. Immunohistochemical staining for CD117, MMP-7, nestin, and marker of proliferation Ki-67 was performed. The correlations between the positive results for Ki-67, CD117, MMP-7, and nestin were evaluated relative to the tumor characteristics of size, localization, grade, cellular type, cellularity, cytology type, growth pattern, ulceration, necrosis, hemorrhage, invasion depth, and lymph node metastasis.

resultsThe tumor was localized in the stomach in 42 of the patients, the intestines in 19, the colon in 7, and the rectum in 4. Comparisons among the groups showed that MMP-7 was correlated with the tumor grade (p<0.001), cellularity (p<0.009), cytologic atypia (p<0.001), ulceration (p=0.002), necrosis (p<0.001), and tumor size (p=0.001). Nestin was correlated with the tumor grade (p=0.013), and tumor size (p=0.024). Correlations among CD117, MMP-7, nestin, and Ki-67 were examined. Nestin and Ki-67 were both significantly correlated with CD117 and MMP-7 [(r=0.279, p=0.018), (r=0.322, p=0.006), (r=0.386, p=0.001), (r=0.386, p=0.002)], respectively.

conclusionsMMP-7 and nestin may be beneficial as markers, given their sensitivity to gastrointestinal stromal tumors.

Indexed as

AdultAgedAged, 80 and overCell NucleusGastrointestinal Stromal TumorsHumansKi-67 AntigenMatrix Metalloproteinase 7Middle AgedNestinProto-Oncogene MasProto-Oncogene Proteins c-kitStaining and LabelingKi-67 AntigenMAS1 protein, humanMatrix Metalloproteinase 7MMP7 protein, humanNES protein, humanNestinProto-Oncogene MasProto-Oncogene Proteins c-kit

Identifiers

PMID24755685
PMCPMC4005864
OpenAlexW2009856691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.