SynthesisPloS one2014
Apolipoprotein E gene polymorphism and risk for coronary heart disease in the Chinese population: a meta-analysis of 61 studies including 6634 cases and 6393 controls.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis.Translational psychiatry · 2020Pooled it
- Apolipoprotein E Gene Variants and Risk of Coronary Heart Disease: A Meta-Analysis.BioMed research international · 2016Pooled it
- CLU rs2279590 polymorphism contributes to Alzheimer's disease susceptibility in Caucasian and Asian populations.Journal of neural transmission (Vienna, Austria : 1996) · 2015Pooled it
- Association of coronary artery bypass with cognitive impairment in coronary artery disease across APO (ε) genotypes in AllofUS.medRxiv : the preprint server for health sciences · 2026Article
- Association of coronary artery bypass with cognitive impairment in coronary artery disease across APO (ε) genotypes in AllofUS.BMJ neurology open · 2026Article
- Review
- Article
- Mediation of the APOE associations with Alzheimer's and coronary heart diseases through body mass index and lipids.GeroScience · 2022Article
- Article
- APOE gene ɛ4 allele (388C-526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population.Journal of clinical laboratory analysis · 2021Article
- Review
- Association of Apolipoprotein E Polymorphism with Adipokines and Cardiovascular Disease Risk in Rheumatoid Arthritis Patients.Life (Basel, Switzerland) · 2020Article
- Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study.Nutrients · 2019Article
- The Genetic Variability ofGenes · 2019Review
- The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype.Lipids in health and disease · 2018Article
- Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment.Diseases (Basel, Switzerland) · 2018Article
- Apolipoprotein E polymorphisms are associated with ischemic stroke susceptibility in a Northwest China Han population.Bioscience reports · 2017Article
- Atherosclerotic and thrombotic genetic and environmental determinants in Egyptian coronary artery disease patients: a pilot study.BMC cardiovascular disorders · 2017Observational
- The Associations between Apolipoprotein E Gene Epsilon2/Epsilon3/Epsilon4 Polymorphisms and the Risk of Coronary Artery Disease in Patients with Type 2 Diabetes Mellitus.Frontiers in physiology · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous studies have evaluated the association between the apolipoprotein E (apoE) gene polymorphisms in coronary heart disease (CHD). However, the results remain uncertain. We carried out a meta-analysis to derive a more comprehensive estimation of the association in Chinese population.
methodsCase-control studies in Chinese and English publications were identified by searching databases of PubMed, EMBASE, Web of Science, CNKI, CBM, Wanfang, VIP and hand searching of relevant journals and the reference lists of retrieved articles. Odds ratio (OR) and 95% confidence interval (CI) were applied to assess the strength of the associations. Subgroup analysis and sensitivity analysis were performed to explore the between-study heterogeneity.
resultsWe finally identified 61 relevant studies which comprised 6634 case-patients and 6393 controls. The pooled OR for ε4 carriers was 96% higher than the ε3/3 genotype for CHD (OR, 1.96; 95% CI, 1.70 to 2.24; P<0.001). However, there was no evidence of statistically significant association between ε2 carriers and risk of CHD (OR, 1.02; 95% CI, 0.91 to 1.13; P = 0.729). In the subgroup analysis, different endpoints may partially account for the heterogeneity. No publication bias was found.
conclusionsOur meta-analysis suggests that the apoE ε4 allele may be a risk factor for CHD in the Chinese population, however, ε2 allele has no significant association.
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