ArticlePloS one2014
Human spotted fever group rickettsioses are underappreciated in southern Taiwan, particularly for the species closely-related to Rickettsia felis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Selection of Diagnostic Cutoffs for Murine Typhus IgM and IgG Immunofluorescence Assay: A Systematic Review.The American journal of tropical medicine and hygiene · 2020Pooled it
- Epidemiology of Murine Typhus in Taiwan from 2013 to 2020.The American journal of tropical medicine and hygiene · 2024Article
- Diagnosis of a RareCase reports in infectious diseases · 2024Article
- First detection and molecular identification of Rickettsia massiliae, a human pathogen, in Rhipicephalus sanguineus ticks collected from Southern Taiwan.PLoS neglected tropical diseases · 2022Article
- First detection and genetic identification of Rickettsia infection in Rhipicephalus sanguineus (Acari: Ixodidae) ticks collected from Southern Taiwan.Experimental & applied acarology · 2021Article
- Seroepidemiological Study of Spotted Fever Group Rickettsiae and Identification of a Putative New Species,Pathogens (Basel, Switzerland) · 2021Article
- Neglected human Rickettsia felis infection in Taiwan: A retrospective seroepidemiological survey of patients with suspected rickettsioses.PLoS neglected tropical diseases · 2021Article
- Clinical Aspects and Detection of Emerging Rickettsial Pathogens: A "One Health" Approach Study in Serbia, 2020.Frontiers in microbiology · 2021Article
- Review
- Diagnosis of spotted fever groupEpidemiology and infection · 2019Review
- The Re-Emergence and Emergence of Vector-Borne Rickettsioses in Taiwan.Tropical medicine and infectious disease · 2017Review
- Rickettsial seropositivity in the indigenous community and animal farm workers, and vector surveillance in Peninsular Malaysia.Emerging microbes & infections · 2017Article
- Significance of major international seaports in the distribution of murine typhus in Taiwan.PLoS neglected tropical diseases · 2017Article
- Spotted Fever Group Rickettsioses and Murine Typhus in a Malaysian Teaching Hospital.The American journal of tropical medicine and hygiene · 2016Article
- Sennetsu Neorickettsiosis, Spotted Fever Group, and Typhus Group Rickettsioses in Three Provinces in Thailand.The American journal of tropical medicine and hygiene · 2016Article
- Severe scrub typhus infection: Clinical features, diagnostic challenges and management.World journal of critical care medicine · 2015Review
- Rickettsia felis Infection among Humans, Bangladesh, 2012-2013.Emerging infectious diseases · 2015Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite increased identification of spotted fever group rickettsioses (SFGR) in animals and arthropods, human SFGR are poorly characterized in Taiwan.
methodsPatients with suspected Q fever, scrub typhus, murine typhus, leptospirosis, and dengue fever from April 2004 to December 2009 were retrospectively investigated for SFGR antibodies (Abs). Sera were screened for Rickettsia rickettsii Abs by indirect immunofluorescence antibody assay (IFA), and those with positive results were further examined for Abs against R. rickettsii, R. typhi, R. felis, R. conorii, and R. japonica using micro-immunofluorescence (MIF) tests. Polymerase chain reaction (PCR) for detection of SFGR DNA was applied in those indicated acute infections. Case geographic distribution was made by the geographic information system software.
resultsA total of 413 cases with paired serum, including 90 cases of Q fever, 47 cases of scrub typhus, 12 cases of murine typhus, 6 cases of leptospirosis, 3 cases of dengue fever, and 255 cases of unknown febrile diseases were investigated. Using IFA tests, a total of 49 cases with 47 (11.4%) and 4 (1.0%) cases had sera potentially positive for R. rickettsii IgG and IgM, respectively. In the 49 cases screened from IFA, MIF tests revealed that there were 5 cases of acute infections (3 possible R. felis and 2 undetermined SFGR) and 13 cases of past infections (3 possible R. felis and 10 undetermined SFGR). None of the 5 cases of acute infection had detectable SFGR DNA in the blood specimen by PCR. Possible acute infection of R. felis was identified in both one case of Q fever and scrub typhus. The geographic distribution of SFGR cases is similar with that of scrub typhus.
conclusionsHuman SFGR exist and are neglected diseases in southern Taiwan, particularly for the species closely-related to R. felis.
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