ArticleThe Plant cell2014
The Rice Basic Helix-Loop-Helix Transcription Factor TDR INTERACTING PROTEIN2 Is a Central Switch in Early Anther Development.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed, 245 citations in OpenAlex.
- The nuclear lamina protein NEMP1 regulates tapetal programmed cell death and pollen development in rice.aBIOTECH · 2026Article
- The SbTDR gene is required for anther development and male fertility in Sorghum bicolor.Plant reproduction · 2026Article
- Strictosidine Synthase-like GeneGenes · 2026Article
- Small Anther, a CPlants (Basel, Switzerland) · 2026Article
- Unlocking wheat fertility: map-based cloning spotlights anther-specific TaAGO5c as a master modulator.The Plant journal : for cell and molecular biology · 2026Article
- Genome-wide regulatory and interaction landscape underlying the functional divergence of rice AGAMOUS-like transcription factors.Journal of experimental botany · 2026Article
- The ATP-Citrate Lyase Subunit ACLA, Coordinates Rice Pollen Development by Coupling Transcriptional Regulation with Metabolic Homeostasis.Rice (New York, N.Y.) · 2026Article
- OsMT2b Regulates Pollen Development and ROS Homeostasis in a Photoperiod-Dependent Manner.Plant biotechnology journal · 2026Article
- Identification of a new male sterile gene BrATAF1 of Chinese cabbage.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Developing an Efficient System for Hybrid Rice Seed Production Using Partial Male Sterility.Plant biotechnology journal · 2026Article
- Two to tango: DTT1 regulates barley tapetum transition as part of a paired key.The Plant cell · 2025Article
- bHLH Transcription Factors in Cereal Crops: Diverse Functions in Regulating Growth, Development and Stress Responses.International journal of molecular sciences · 2025Review
- The basic helix-loop-helix (bHLH) transcription factor DTT1 is part of a paired key that unlocks the tapetum transition in barley anther development.The Plant cell · 2025Article
- Meiotic cytokinesis defects in cultured Arabidopsis flowers induce diploid microspores.Plant reproduction · 2025Article
- Natural allelic variation of basic helix-loop-helix transcription factor 25 regulates carotenoid biosynthesis in sweet potato.Plant biotechnology journal · 2025Article
- Unraveling the Multilayered Regulatory Networks of miRNAs and PhasiRNAs inPlants (Basel, Switzerland) · 2025Article
- Genetic and molecular mechanisms underlying the male sterility in rice.Journal of applied genetics · 2025Review
- Advances in plant male sterility for hybrid seed production: an overview of conditional nuclear male sterile lines and biotechnology-based male sterile systems.Frontiers in plant science · 2025Review
- Unlocking male sterility in horticultural crops through gene editing technology for precision breeding applications: presentation of a case study in tomato.Frontiers in plant science · 2025Article
- OsALKBH9-mediated mPlant biotechnology journal · 2024Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In male reproductive development in plants, meristemoid precursor cells possessing transient, stem cell-like features undergo cell divisions and differentiation to produce the anther, the male reproductive organ. The anther contains centrally positioned microsporocytes surrounded by four distinct layers of wall: the epidermis, endothecium, middle layer, and tapetum. Here, we report that the rice (Oryza sativa) basic helix-loop-helix (bHLH) protein TDR INTERACTING PROTEIN2 (TIP2) functions as a crucial switch in the meristemoid transition and differentiation during early anther development. The tip2 mutants display undifferentiated inner three anther wall layers and abort tapetal programmed cell death, causing complete male sterility. TIP2 has two paralogs in rice, TDR and EAT1, which are key regulators of tapetal programmed cell death. We revealed that TIP2 acts upstream of TDR and EAT1 and directly regulates the expression of TDR and EAT1. In addition, TIP2 can interact with TDR, indicating a role of TIP2 in later anther development. Our findings suggest that the bHLH proteins TIP2, TDR, and EAT1 play a central role in regulating differentiation, morphogenesis, and degradation of anther somatic cell layers, highlighting the role of paralogous bHLH proteins in regulating distinct steps of plant cell-type determination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.