ArticleeLife2014
Gating of neural error signals during motor learning.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Subthreshold violations of trajectory predictions are sensitive to TMS of cerebellum Crus I/II.Neuroimage. Reports · 2026Article
- Synchronous climbing fiber activity enables instructive signaling for cerebellar learning through modulation of disinhibitory circuits.Nature neuroscience · 2026Article
- Temporal dynamics of Purkinje cell-intrinsic excitability governs cerebellar systems consolidation.iScience · 2025Article
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- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- How neural systems transform synaptic plasticity into behavioral learning.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Impaired cerebellar plasticity hypersensitizes sensory reflexes in SCN2A-associated ASD.Neuron · 2024Article
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- Properties of Gaze Strategies Based on Eye-Head Coordination in a Ball-Catching Task.Vision (Basel, Switzerland) · 2024Article
- Systemic pharmacological suppression of neural activity reverses learning impairment in a mouse model of Fragile X syndrome.bioRxiv : the preprint server for biology · 2024Article
- Interactions between circuit architecture and plasticity in a closed-loop cerebellar system.eLife · 2024Article
- Impaired cerebellar plasticity hypersensitizes sensory reflexes inbioRxiv : the preprint server for biology · 2023Article
- Cerebellar associative learning underlies skilled reach adaptation.Nature neuroscience · 2023Article
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons.The Journal of general physiology · 2023Article
- Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- The Rules of Cerebellar Learning: Around the Ito Hypothesis.Neuroscience · 2021Review
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5 authors.
Funding
Abstract
Cerebellar climbing fiber activity encodes performance errors during many motor learning tasks, but the role of these error signals in learning has been controversial. We compared two motor learning paradigms that elicited equally robust putative error signals in the same climbing fibers: learned increases and decreases in the gain of the vestibulo-ocular reflex (VOR). During VOR-increase training, climbing fiber activity on one trial predicted changes in cerebellar output on the next trial, and optogenetic activation of climbing fibers to mimic their encoding of performance errors was sufficient to implant a motor memory. In contrast, during VOR-decrease training, there was no trial-by-trial correlation between climbing fiber activity and changes in cerebellar output, and climbing fiber activation did not induce VOR-decrease learning. Our data suggest that the ability of climbing fibers to induce plasticity can be dynamically gated in vivo, even under conditions where climbing fibers are robustly activated by performance errors. DOI: http://dx.doi.org/10.7554/eLife.02076.001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.