ArticleBMC neurology2014
NQO1 gene rs1800566 variant is not associated with risk for multiple sclerosis.
Article in BMC neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Oxidative Stress Markers in Multiple Sclerosis.International journal of molecular sciences · 2024Review
- Impact of NQO1 dysregulation in CNS disorders.Journal of translational medicine · 2024Review
- Association betweenInternational journal of molecular sciences · 2022Article
- Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway.Molecular biology reports · 2022Review
- Association of NQO1 levels and its genetic polymorphism with susceptibility to methamphetamine dependence.Molecular genetics & genomic medicine · 2021Article
- Endothelial nitric oxide synthase (NOS3) rs2070744 polymorphism and risk for multiple sclerosis.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Heme Oxygenase-1 and 2 Common Genetic Variants and Risk for Multiple Sclerosis.Scientific reports · 2016Article
- The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis.Cellular & molecular immunology · 2015Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an association between the SNP rs1800566 in the NQO1 gene and the risk for MS in the Greek population. The aim of this study was to replicate a possible influence of the. SNP rs1800566 in the NQO1 gene in the risk for MS in the Spanish Caucasian population.
methodsWe analyzed allelic and genotypic frequency of NQO1 rs1800566 in 290 patients with MS and 310 healthy controls, using TaqMan Assays.
resultsNQO1 rs1800566 allelic and genotypic frequencies did not differ significantly between MS patients and controls, and were unrelated with age of onset of MS, gender, and clinical type of MS.
conclusionsOur results indicate that NQO1 rs1800566 does not have an effect on MS disease risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.