ArticleJournal of the American College of Surgeons2014
Epidemiology and outcomes of community-acquired Clostridium difficile infections in Medicare beneficiaries.
Article in Journal of the American College of Surgeons, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Global burden ofJournal of global health · 2019Pooled it
- Review
- Approaching pathogenicbioRxiv : the preprint server for biology · 2024Article
- Effect of clinical versus administrative data definitions on the epidemiology of C. difficile among hospitalized individuals with IBD: a population-based cohort study.BMC gastroenterology · 2022Article
- Gut microbiota and microbiota-based therapies forFrontiers in medicine · 2022Review
- Health care resource utilization and costs of recurrentJournal of managed care & specialty pharmacy · 2021Article
- Upper Gastrointestinal Perforations: A Possible Danger of Antibiotic Overuse.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Acute Kidney Injury Due to Diarrheal Illness Requiring Hospitalization: Data from the National Inpatient Sample.Journal of general internal medicine · 2018Article
- Post-hospitalization Treatment Regimen and Readmission for C. difficile Colitis in Medicare Beneficiaries.World journal of surgery · 2018Article
- Evaluation of the BioFire FilmArray® GastrointestinalPanel in a Midwestern Academic Hospital.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Article
- Proton Pump Inhibitors Do Not Increase Risk for Clostridium difficile Infection in the Intensive Care Unit.The American journal of gastroenterology · 2016Article
- Management of Inflammatory Bowel Disease in the Elderly.Current treatment options in gastroenterology · 2016Review
- Epidemiology and Risk Factors for Community-Associated Clostridium difficile Infection: A Narrative Review.Infectious diseases and therapy · 2016Review
- Antibiotic prophylaxis and risk of Clostridium difficile infection after coronary artery bypass graft surgery.The Journal of thoracic and cardiovascular surgery · 2016Article
- Cost-Effectiveness Analysis of Six Strategies to Treat Recurrent Clostridium difficile Infection.PloS one · 2016Article
- Challenges in the Diagnosis and Management of Inflammatory Bowel Disease in the Elderly.Current treatment options in gastroenterology · 2015Article
- Review
- Clostridium Difficile Infection from a Surgical Perspective.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Review
- Flooding and Clostridium difficile Infection: A Case-Crossover Analysis.International journal of environmental research and public health · 2015Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe incidence of community-acquired Clostridium difficile (CACD) is increasing in the United States. Many CACD infections occur in the elderly, who are predisposed to poor outcomes. We aimed to describe the epidemiology and outcomes of CACD in a nationally representative sample of Medicare beneficiaries. STUDY
designWe queried a 5% random sample of Medicare beneficiaries (2009-2011 Part A inpatient and Part D prescription drug claims; n = 864,604) for any hospital admission with a primary ICD-9 diagnosis code for C difficile (008.45). We examined patient sociodemographic and clinical characteristics, preadmission exposure to oral antibiotics, earlier treatment with oral vancomycin or metronidazole, inpatient outcomes (eg, colectomy, ICU stay, length of stay, mortality), and subsequent admissions for C difficile.
resultsA total of 1,566 (0.18%) patients were admitted with CACD. Of these, 889 (56.8%) received oral antibiotics within 90 days of admission. Few were being treated with oral metronidazole (n = 123 [7.8%]) or vancomycin (n = 13 [0.8%]) at the time of admission. Although 223 (14%) patients required ICU admission, few (n = 15 [1%]) underwent colectomy. Hospital mortality was 9%. Median length of stay among survivors was 5 days (interquartile range 3 to 8 days). One fifth of survivors were readmitted with C difficile, with a median follow-up time of 393 days (interquartile range 129 to 769 days).
conclusionsNearly half of the Medicare beneficiaries admitted with CACD have no recent antibiotic exposure. High mortality and readmission rates suggest that the burden of C difficile on patients and the health care system will increase as the US population ages. Additional efforts at primary prevention and eradication might be warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.