ArticleJournal of the American Heart Association2014
Risk factors and outcome of Fontan-associated plastic bronchitis: a case-control study.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- Lymphatic Imaging and Interventions in Children: Current Practice.Cardiovascular and interventional radiology · 2026Review
- Contemporary outcomes of the Fontan operation: An Australian and New Zealand Fontan Registry study.JTCVS open · 2026Article
- Functionally Single-Ventricle Complications After Fontan Palliation-A Narrative Review.Journal of clinical medicine · 2026Review
- Research advances of tubeless thoracic surgery for pulmonary nodules: current status and future challenges.Frontiers in surgery · 2026Review
- A literature review: progress in the study of plastic bronchitis.Frontiers in pediatrics · 2026Review
- Plastic Bronchitis: Extensive Cast Expectoration in a 6-Year-Old Boy with Fontan Circulation.Diagnostics (Basel, Switzerland) · 2025Article
- Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation.JACC. Advances · 2025Article
- Clinical approach for pulmonary lymphatic disorders.World journal of clinical cases · 2024Article
- Clinical features of plastic bronchitis in children after congenital heart surgery.Italian journal of pediatrics · 2024Article
- Current diagnostic and therapeutic strategies for the management of lymphatic insufficiency in patients with hypoplastic left heart syndrome.Frontiers in pediatrics · 2023Review
- Current Treatment Options for the Failing Fontan Circulation.Current cardiology reviews · 2022Review
- The pathophysiology and complications of Fontan circulation.Acta bio-medica : Atenei Parmensis · 2021Review
- Reaching consensus for unified medical language in Fontan care.ESC heart failure · 2021Article
- Bronchial casts associated withThe Journal of international medical research · 2020Article
- Current evaluation and management of plastic bronchitis in the pediatric population.International journal of pediatric otorhinolaryngology · 2020Article
- Routine Surveillance Catheterization is Useful in Guiding Management of Stable Fontan Patients.Pediatric cardiology · 2020Article
- Molecular Approaches in Single Ventricle Management.Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual · 2020Review
- Transplantation of the failing Fontan.Translational pediatrics · 2019Review
- Hypoplastic left heart syndrome: From bedside to bench and back.Journal of molecular and cellular cardiology · 2019Review
- Analysis of Inflammatory Cytokines in Postoperative Fontan Pleural Drainage.Pediatric cardiology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe onset of plastic bronchitis (PB) can be debilitating in survivors of Fontan surgery. The rarity of this complication makes designing studies to understand risk factors for PB challenging. This 2-center case-control study aimed to describe patient outcomes and to assess the association of antecedent patient factors with PB development. METHODS AND
resultsUsing center registries, PB patients (n=25) were matched 1:2 to non-PB Fontans (n=43) by date of Fontan surgery and center. The groups were compared for baseline characteristics. Association of patient characteristics with PB was assessed using logistic regression and of potential risk factors with onset of PB using time-to-event analyses. The median time from Fontan to PB diagnosis was 2.5 years. Overall, 12/25 PB patients died or underwent heart transplant; the median transplant-free survival was 8.3 years after diagnosis. Factors associated with developing PB included post-surgical chylothorax (44% PB versus 10% control; odds ratio [OR] 7.3; P=0.003), chest tube (CT) duration at stage 2 (P=0.04) and Fontan (P=0.004), and postoperative ascites (36% PB versus 12% control; OR 4.2; P=0.003). CT drainage >13 days at Fontan was associated with earlier PB onset (P=0.04). Early-onset PB was associated with an increased risk of death (OR 5.0; P=0.002).
conclusionsPB is a life-threatening disorder. A longer duration of CT drainage after surgery, chylothorax, and development of ascites are all associated with developing PB. Understanding the pathophysiology of peri-operative complications in individual patients and using targeted interventions may delay the onset of the PB phenotype.
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