ArticleParasites & vectors2014
Neurotoxocarosis: marked preference of Toxocara canis for the cerebrum and T. cati for the cerebellum in the paratenic model host mouse.
Article in Parasites & vectors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain.Nature communications · 2026Article
- Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stagesBiomedica : revista del Instituto Nacional de Salud · 2026Article
- The potential relationship between Toxocara canis infection and epilepsy in a rat model.Parasitology research · 2025Article
- No evidence of Alzheimer's disease pathology in mice infected with Toxocara canis.Parasite (Paris, France) · 2025Article
- Efficacy of artemether against toxocariasis in mice: parasitological and immunopathological changes in brain, liver, and lung.Pathogens and global health · 2024Article
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- Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice.PLoS pathogens · 2022Article
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- Case-Control Study to Assess the Association between Epilepsy andMicroorganisms · 2021Article
- Clinical spectrum of symptoms in cerebral Toxocariasis (Review).Experimental and therapeutic medicine · 2021Review
- Role of cats in human toxocarosis.Companion animal · 2020Article
- "Begging the Question"-DoesPathogens (Basel, Switzerland) · 2020Article
- Mesenchymal stem cells combined with albendazole as a novel therapeutic approach for experimental neurotoxocariasis.Parasitology · 2020Article
- Toxocara species environmental contamination of public spaces in New York City.PLoS neglected tropical diseases · 2020Article
- Larval distribution, migratory pattern and histological effects ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2019Article
- Parasites in brains of wild rodents (Arvicolinae and Murinae) in the city of Leipzig, Germany.International journal for parasitology. Parasites and wildlife · 2019Article
- Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis.PLoS neglected tropical diseases · 2019Article
- Histopathological characterization of Toxocara canis- and T. cati-induced neurotoxocarosis in the mouse model.Parasitology research · 2019Article
- Neuroinvasion of Toxocara canis- and T. cati-larvae mediates dynamic changes in brain cytokine and chemokine profile.Journal of neuroinflammation · 2019Article
- Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host.Parasites & vectors · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfective larvae of the worldwide occurring zoonotic roundworm T. canis exhibit a marked affinity to the nervous tissues of paratenic hosts. In humans, most cases of neurotoxocarosis are considered to be caused by larvae of T. canis as T. cati larvae have rarely been found in the CNS in previous studies. However, direct comparison of studies is difficult as larval migration depends on a variety of factors including mouse strains and inoculation doses. Therefore, the present study aims to provide a direct comparison of both roundworm species in mice as a model for paratenic hosts with specific focus on the CNS during the acute and chronic phase of disease to provide a basis for further studies dealing with neurotoxocarosis.
methodsC57Bl/6J mice were infected with 2000 embryonated T. canis and T. cati eggs, respectively as well as Balb/c mice infected with T. cati eggs only. On 8 time points post infection, organs were removed and microscopically examined for respective larvae. Special focus was put on the CNS, including analysis of larval distribution in the cerebrum and cerebellum, right and left hemisphere as well as eyes and spinal cord. Additionally, brains of all infection groups as well as uninfected controls were examined histopathologically to characterize neurostructural damage.
resultsSignificant differences in larval distribution were observed between and within the infection groups during the course of infection. As expected, significantly higher recovery rates of T. canis than T. cati larvae were determined in the brain. Surprisingly, significantly more T. canis larvae could be found in cerebra of infected mice whereas T. cati larvae were mainly located in the cerebellum. Structural damage in brain tissue could be observed in all infection groups, being more severe in brains of T. canis infected mice.
conclusionsThe data obtained provides an extensive characterization of migrational routes of T. canis and T. cati in the paratenic host mouse in direct comparison. Even though to a lesser extent, structural damage in the brain was also caused by T. cati larvae and therefore, the potential as pathogenic agents should not be underestimated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.