ReviewAnnals of the American Thoracic Society2014
Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases.
Review in Annals of the American Thoracic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Bacterial lysate therapy for the prevention of wheezing episodes and asthma exacerbations: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2020Pooled it
- Association between volatile organic compound concentrations in daycares and child wheeze: the French CRESPI study.Environmental health : a global access science source · 2026Article
- How early life respiratory viral infections impact airway epithelial development and may lead to asthma.Frontiers in pediatrics · 2024Review
- Creatine Kinase Is Decreased in Childhood Asthma.American journal of respiratory and critical care medicine · 2023Article
- Dexmedetomidine as an adjunctive treatment for acute asthma.Clinical and experimental emergency medicine · 2021Article
- Cigarette Smoke Exposure, Pediatric Lung Disease, and COVID-19.Frontiers in physiology · 2021Review
- Article
- Viral infections and wheezing-asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?Clinical and translational allergy · 2020Review
- Practical and Conceptual Considerations for the Primary Prevention of Asthma.Clinics in chest medicine · 2019Review
- Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction.American journal of respiratory and critical care medicine · 2018Review
- Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology.Journal of cellular physiology · 2017Article
- Prenatal exposures and the development of childhood wheezing illnesses.Current opinion in allergy and clinical immunology · 2017Review
- Mechanisms Mediating Pediatric Severe Asthma and Potential Novel Therapies.Frontiers in pediatrics · 2017Review
- Better understanding of childhood asthma, towards primary prevention - are we there yet? Consideration of pertinent literature.F1000Research · 2017Review
- The microbiome and development of allergic disease.Current opinion in allergy and clinical immunology · 2016Review
- Changing Trends in Asthma Prevalence Among Children.Pediatrics · 2016Article
- Future Research Directions in Asthma. An NHLBI Working Group Report.American journal of respiratory and critical care medicine · 2015Review
- Asthma.Nature reviews. Disease primers · 2015Review
- Promising candidates for allergy prevention.The Journal of allergy and clinical immunology · 2015Review
- Microbiota in allergy and asthma and the emerging relationship with the gut microbiome.Cell host & microbe · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
Asthma is a common disease with enormous public health costs, and its primary prevention is an ambitious and important goal. Understanding of how host and environmental factors interact to cause asthma is incomplete, but persistent questions about mechanisms should not stop clinical research efforts aimed at reducing the prevalence of childhood asthma. Achieving the goal of primary prevention of asthma will involve integrated and parallel sets of research activities in which mechanism-oriented studies of asthma inception proceed alongside clinical intervention studies to test biologically plausible prevention ideas. For example, continued research is needed, particularly in young children, to uncover biomarkers that identify asthma risk and provide potential targets of intervention, and to improve understanding of the role of microbial factors in asthma risk and disease initiation. In terms of clinical trials that could be initiated now or in the near future, we recommend three interventions for testing: (1) preventing asthma through prophylaxis against respiratory syncytial virus and human rhinovirus infections of the airway; (2) immune modulation, using prebiotics, probiotics, and bacterial lysates; and (3) prevention of allergen sensitization and allergic inflammation, using anti-IgE. These interventions should be tested while other, more universal prevention measures that may promote lung health are also investigated. These potential universal lung health measures include prevention of preterm delivery; reduced exposure of the fetus and young infant to environmental pollutants, including tobacco smoke; prevention of maternal and child obesity; and management of psychosocial stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.