Trial reportRadiology2014
Coronary artery plaque volume and obesity in patients with diabetes: the factor-64 study.
Trial report in Radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of weight reduction on the severity of lower urinary tract symptoms in obese male patients with benign prostatic hyperplasia: a randomized controlled trial.Korean journal of urology · 2015Trial
- Computed Tomography Coronary Angiography Is Feasible and Reliable for Proximal Coronary Segment Interpretation in Patients with Elevated Body Mass Index.Journal of cardiovascular development and disease · 2024Article
- Cardiovascular Protective Properties of GLP-1 Receptor Agonists: More than Just Diabetic and Weight Loss Drugs.Journal of clinical medicine · 2024Review
- Article
- Cardiovascular risk factors and pericardial fat volume as predictors of coronary atherosclerosis burden in postmenopausal women: A retrospective, single center study.Health science reports · 2023Article
- Positron emission tomographic studies of the association between atherogenesis and aortitis among psoriatic patients.Archives of medical science : AMS · 2023Article
- Coronary calcium density in relation to coronary heart disease and cardiovascular disease in adults with diabetes or metabolic syndrome: the Multi-ethnic Study of Atherosclerosis (MESA).BMC cardiovascular disorders · 2022Article
- The relationship between sugar-sweetened beverages, sleep disorders, and diabesity.Frontiers in endocrinology · 2022Article
- Impaired Coronary Blood Flow in Patients with Psoriasis: Findings from an Observational Cohort Study.The Journal of investigative dermatology · 2021Observational
- Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging.Nature reviews. Cardiology · 2021Review
- Application of machine learning to determine top predictors of noncalcified coronary burden in psoriasis: An observational cohort study.Journal of the American Academy of Dermatology · 2020Observational
- Association Among Noncalcified Coronary Burden, Fractional Flow Reserve, and Myocardial Injury in Psoriasis.Journal of the American Heart Association · 2020Article
- Quantitative coronary computed tomography angiography for the detection of cardiac allograft vasculopathy.European radiology · 2020Article
- Association Between Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 and Coronary Artery Disease in Psoriasis.JAMA dermatology · 2020Article
- Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis: A Prospective Cohort Study.JACC. Cardiovascular imaging · 2020Observational
- Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study.Cardiovascular research · 2019Observational
- Progression of coronary atherosclerotic plaque burden and relationship with adverse cardiovascular event in asymptomatic diabetic patients.BMC cardiovascular disorders · 2019Article
- Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis.JACC. Basic to translational science · 2019Article
- Association Between Aortic Vascular Inflammation and Coronary Artery Plaque Characteristics in Psoriasis.JAMA cardiology · 2018Article
- Prognostic value of coronary atherosclerosis progression evaluated by coronary CT angiography in patients with stable angina.European radiology · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo determine the relationship between coronary plaque detected with coronary computed tomographic (CT) angiography and clinical parameters and cardiovascular risk factors in asymptomatic patients with diabetes. MATERIALS AND
methodsAll patients signed institutional review board-approved informed consent forms before enrollment. Two hundred twenty-four asymptomatic diabetic patients (121 men; mean patient age, 61.8 years; mean duration of diabetes, 10.4 years) underwent coronary CT angiography. Total coronary artery wall volume in all three vessels was measured by using semiautomated software. The coronary plaque volume index (PVI) was determined by dividing the wall volume by the coronary length. The relationship between the PVI and cardiovascular risk factors was determined with multivariable analysis.
resultsThe mean PVI (±standard deviation) was 11.2 mm(2) ± 2.7. The mean coronary artery calcium (CAC) score (determined with the Agatston method) was 382; 67% of total plaque was noncalcified. The PVI was related to age (standardized β = 0.32, P < .001), male sex (standardized β = 0.36, P < .001), body mass index (BMI) (standardized β = 0.26, P < .001), and duration of diabetes (standardized β = 0.14, P = .03). A greater percentage of soft plaque was present in younger individuals with a shorter disease duration (P = .02). The soft plaque percentage was directly related to BMI (P = .002). Patients with discrepancies between CAC score and PVI rank quartiles had a higher percentage of soft and fibrous plaque (18.7% ± 3.3 vs 17.4% ± 3.5 [P = .008] and 52.2% ± 7.2 vs 47.2% ± 8.8 [P < .0001], respectively).
conclusionIn asymptomatic diabetic patients, BMI was the primary modifiable risk factor that was associated with total and soft coronary plaque as assessed with coronary CT angiography.
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