ArticleFetal and pediatric pathology2014
Autoimmune hepatitis and primary sclerosing cholangitis in children and adolescents.
Article in Fetal and pediatric pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Primary sclerosing cholangitis in children with inflammatory bowel disease: An ESPGHAN position paper from the Hepatology Committee and the IBD Porto group.Journal of pediatric gastroenterology and nutrition · 2025Guideline
- Acute Liver Failure During Early Pregnancy-Case Report and Review of Literature.Journal of clinical medicine · 2025Article
- Autoimmune Hepatitis: A Diagnostic and Therapeutic Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Use of oral vancomycin in children with autoimmune liver disease: A single centre experience.World journal of hepatology · 2021Article
- Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis.Pathologica · 2021Review
- Cholangiopathies - Towards a molecular understanding.EBioMedicine · 2018Review
- Comprehensive Review of Molecular Mechanisms during Cholestatic Liver Injury and Cholangiocarcinoma.Journal of liver · 2018Article
- A New Mutation Causing Progressive Familiar Intrahepatic Cholestasis Type 3 in Association with Autoimmune Hepatitis.European journal of case reports in internal medicine · 2017Article
- Clinical course and prognosis of pediatric-onset primary sclerosing cholangitis.United European gastroenterology journal · 2016Article
- Clinical Presentation and Outcomes of Autoimmune Hepatitis in Inflammatory Bowel Disease.Digestive diseases and sciences · 2015Review
- Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics.World journal of gastroenterology · 2015Review
- Hellenic Association for the Study of the Liver Clinical Practice Guidelines: Autoimmune hepatitis.Annals of gastroenterologyArticle
- Hellenic Association for the Study of the Liver (HASL): revised clinical practice guidelines for autoimmune hepatitis.Annals of gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledClinical presentation and histopathology of autoimmune hepatitis (AIH) and primary sclerosing cholangitis (PSC) overlap syndrome (OS) are similar, but their management is different. We conducted a pediatric retrospective cross-sectional study of 34 patients with AIH and PSC. AIH had female predominance (74%) and was lower in PSC (45%). There was a trend toward higher frequency of blacks in PSC/OS (55%) compared to Caucasians (36%) and Hispanics (9%), but not race differences in AIH. Inflammatory bowel disease (IBD) was present in 75% of PSC/OS. Plasma cells were not specific for AIH (found in 42% of PSC). Concentric fibrosis was not reliable for PSC as was found in 46% of AIH.
conclusionA combination of clinical history, laboratory tests, imaging studies and liver biopsy are required to confirm and properly treat AIH and PSC. Liver biopsy should be used to grade severity and disease progression, but cannot be used alone to diagnose these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.