ArticleAdvanced pharmaceutical bulletin2014
Selenium effect on oxidative stress factors in septic rats.
Article in Advanced pharmaceutical bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Selenium alleviates Staphylococcus aureus-induced mastitis by modulating mitochondrial dynamics and inhibiting the ROS/NLRP3/Pyroptosis pathway.Molecular biology reports · 2025Article
- Protective role of selenium in sepsis: Mechanisms and potential therapeutic strategies.Open medicine (Warsaw, Poland) · 2025Review
- Rutin and Selenium Co-administration Reverse 3-Nitropropionic Acid-Induced Neurochemical and Molecular Impairments in a Mouse Model of Huntington's Disease.Neurotoxicity research · 2020Article
- Antioxidant Solution in Combination with Angiotensin-(1-7) Provides Myocardial Protection in Langendorff-Perfused Rat Hearts.Oxidative medicine and cellular longevity · 2020Article
- Considering the Effect ofTurkish journal of pharmaceutical sciences · 2019Article
- Role of Selenoproteins in Bacterial Pathogenesis.Biological trace element research · 2019Review
- Investigation of antioxidative effects of a cardioprotective solution in heart tissue.Molecular and cellular biochemistry · 2019Article
- Ziziphus spina-christi leaf extract pretreatment inhibits liver and spleen injury in a mouse model of sepsis via anti-oxidant and anti-inflammatory effects.Inflammopharmacology · 2018Article
- Metformin-attenuated sepsis-induced oxidative damages: a novel role for metformin.Iranian journal of basic medical sciences · 2018Article
- Phytochemical Analysis andIranian journal of pharmaceutical research : IJPR · 2018Article
- Investigation of selenium pretreatment in the attenuation of lung injury in rats induced by fine particulate matters.Environmental science and pollution research international · 2017Article
- Effects of gamma oryzanol on factors of oxidative stress and sepsis-induced lung injury in experimental animal model.Iranian journal of basic medical sciences · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSevere oxidative stress is an important event that occurs in patients with sepsis. The body has extensive and multiple defense mechanisms against the reactive oxygen species (ROS) produced during inflammation and sepsis. One of these mechanisms includes a group of enzymes that utilize selenium as their cofactor. The purpose of this study is investigating of Selenium effect on oxidative stress factors in animal model of sepsis.
methodsSepsis was induced by caecal ligation and puncture (CLP) method. 30 Male Wistar rats were divided into following groups: sham group; CLP group; 100 μg/kg Selenium- treated CLP group. 12 hours after inducing sepsis animals were killed and lungs were removed. One of the lungs was frozen in liquid nitrogen and kept at -70°C for enzymatic activity analysis and the other was kept in formalin 10% until tissue section preparation performed for histopathological studies.
resultsThe Myeloperoxidase (MPO) activity was decreased in Selenium- treated CLP group. Inflammation score of lung tissue was lowered in Selenium- treated CLP group, but it wasn't statically significant. Level of glutathione peroxidase (GPx) was higher in CLP and Selenium- treated CLP groups.
conclusionIt seems that Selenium has protective effect on lung inflammation during acute lung injury. Also it may improve some stress oxidative profile during CLP model of sepsis.
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