ReviewFacts, views & vision in ObGyn2013
The uterine myocyte as a target for prevention of preterm birth.
Review in Facts, views & vision in ObGyn, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Comparative analysis of myometrial and vascular smooth muscle cells to determine optimal cells for use in drug discovery.Pharmacological research · 2019Article
- FSH Actions and Pregnancy: Looking Beyond Ovarian FSH Receptors.Endocrinology · 2018Review
- Bitter taste receptors as targets for tocolytics in preterm labor therapy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Differential Regulation of Human and Mouse Myometrial Contractile Activity by FSH as a Function of FSH Receptor Density.Biology of reproduction · 2016Article
- High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility.PloS one · 2015Article
- The effects of Ginseng Java root extract on uterine contractility in nonpregnant rats.Physiological reports · 2014Article
- Development and validation of primary human myometrial cell culture models to study pregnancy and labour.BMC pregnancy and childbirth · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preterm birth (PTB) remains the most common cause of neonatal morbidity and mortality as well as long-term disability. Current strategies to prevent or arrest spontaneous preterm labor (SPTL) have limited success. For almost three decades, there have been no novel pharmacological agents used clinically to address this important obstetrical complication. In this review, we focus on the uterine myocyte as a target for prevention of spontaneous PTB. After presenting an overview of intracellular signaling pathways that are important in regulation of smooth muscle contractility, we discuss previous and current pharmacological approaches to manage SPTL. We also present recent evidence from our own laboratories suggesting a potentially novel and uterine-specific approach to maintain or impose uterine relaxation. Finally, we briefly discuss extrinsic systems that might affect uterine activity and reinforce the concept that SPTL represents a syndrome that is the end result of a variety of pathophysiologic etiologies leading to PTB. We conclude by emphasizing the need for much more research to provide sufficient understanding of the mechanisms of SPTL and to make inroads towards reducing the incidence and adverse consequences of this common and serious syndrome.
Indexed as
Identifiers
24753931PMC3987349W873479635What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.