ArticleCommunicative & integrative biology2013
Interactions between intercellular adhesion molecule-5 positive elements and their surroundings in the rodent visual cortex.
Article in Communicative & integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses.Cells · 2021Review
- Review
- Ultrastructure of geniculocortical synaptic connections in the tree shrew striate cortex.The Journal of comparative neurology · 2016Article
- A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders.Frontiers in cellular neuroscience · 2015Review
- Activity dependent CAM cleavage and neurotransmission.Frontiers in cellular neuroscience · 2015Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The telencephalon-associated intercellular adhesion molecule 5 (Telencephalin; ICAM-5) regulates dendritic maturation, a process dependent on extracellular proteases in the developing brain. Using transmission electron microscopy, we have reported previously that ICAM-5 is localized primarily in dendritic protrusions during a period of robust synaptogenesis (P14 in mouse visual cortex). As dendritic protrusions mature (P28), ICAM-5 immuno-reactivity shifts from dendritic protrusions into dendritic shafts. ICAM-5 immuno-reactivity does not shift in animals lacking the matrix metalloproteinase-9 (MMP-9), a protease shown to regulate ICAM-5 cleavage. Cleaved ICAM-5 (soluble fraction; sICAM-5) has been shown to bind to a number of receptors located in neighboring structures, resulting in a variety of downstream signaling events, including enhanced neurotransmission. Here, we investigated the potential MMP-regulated ICAM-5 signaling by examining the relationship between ICAM-5 immuno-positive elements and the structures that directly neighbor them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.