Evidence map›Paper›PMID 24753722›Full record

ArticleBiomicrofluidics2014

Microfluidic electrical sorting of particles based on shape in a spiral microchannel.

John Dubose, Xinyu Lu, Saurin Patel, Shizhi Qian, Sang Woo Joo, Xiangchun Xuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomicrofluidics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John DuboseDepartment of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634-0921, USA.
Xinyu LuDepartment of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634-0921, USA.
Saurin PatelDepartment of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634-0921, USA.
Shizhi QianInstitute of Micro/Nanotechnology, Old Dominion University, Norfolk, Virginia 23529, USA.
Sang Woo JooSchool of Mechanical Engineering, Yeungnam University, Gyongsan 712-719, South Korea.
Xiangchun XuanDepartment of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634-0921, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We demonstrate in this work a continuous-flow electrical sorting of spherical and peanut-shaped particles of similar volumes in an asymmetric double-spiral microchannel. It exploits curvature-induced dielectrophoresis to focus particles to a tight stream in the first spiral without any sheath flow and subsequently displace them to shape-dependent flow paths in the second spiral without any external force. We also develop a numerical model to simulate and understand this shape-based particle sorting in spiral microchannels. The predicted particle trajectories agree qualitatively with the experimental observation.

Identifiers

PMID24753722
PMCPMC3977798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.