Evidence map›Paper›PMID 24753704›Full record

ArticleJournal of Korean medical science2014

Effects of transglutaminase 2 inhibition on ventilator-induced lung injury.

In Bum Suh, Dae Wui Yoon, Won-Oak Oh, Eun Joo Lee, Kyung Hoon Min, Gyu Young Hur, Seung Heon Lee, Sung Yong Lee, Sang Yeub Lee, Chol Shin and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

In Bum SuhDepartment of Laboratory Medicine, College of Medicine, Kangwon National University, Chuncheon, Korea.ORCID 0000-0001-7012-0305
Dae Wui YoonDivision of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.ORCID 0000-0001-8875-2255
Won-Oak OhCollege of Nursing, Korea University, Seoul, Korea.ORCID 0000-0003-0156-3422
Eun Joo LeeDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.ORCID 0000-0001-7884-9045
Kyung Hoon MinDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.ORCID 0000-0003-0610-2182
Gyu Young HurDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.ORCID 0000-0001-5039-0199
Seung Heon LeeDivision of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.ORCID 0000-0002-7180-3877
Sung Yong LeeDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.ORCID 0000-0002-8693-5792
Sang Yeub LeeDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.ORCID 0000-0001-7565-1076
Chol ShinDivision of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.ORCID 0000-0002-2928-8576
Jae Jeong ShimDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.ORCID 0000-0002-3095-1021
Kwang Ho InDivision of Respiratory and Critical Care Medicine, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Korea.ORCID 0000-0003-3010-6423
Kyung Ho KangDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Korea.ORCID 0000-0002-9778-1725
Je Hyeong KimDivision of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.ORCID 0000-0002-8995-7460
Korea University · KRKorea University Medical Center · KRKorea University · JPKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was performed to examine the role of transglutaminase 2 (TG2) in ventilator-induced lung injury (VILI). C57BL/6 mice were divided into six experimental groups: 1) control group; 2) lipopolysaccharide (LPS) group; 3) lung protective ventilation (LPV) group; 4) VILI group; 5) VILI with cystamine, a TG2 inhibitor, pretreatment (Cyst+VILI) group; and 6) LPV with cystamine pretreatment (Cyst+LPV) group. Acute lung injury (ALI) score, TG2 activity and gene expression, inflammatory cytokines, and nuclear factor-κB (NF-κB) activity were measured. TG2 activity and gene expression were significantly increased in the VILI group (P < 0.05). Cystamine pretreatment significantly decreased TG2 activity and gene expression in the Cyst+VILI group (P < 0.05). Inflammatory cytokines were higher in the VILI group than in the LPS and LPV groups (P < 0.05), and significantly lower in the Cyst+VILI group than the VILI group (P < 0.05). NF-κB activity was increased in the VILI group compared with the LPS and LPV groups (P < 0.05), and significantly decreased in the Cyst+VILI group compared to the VILI group (P = 0.029). The ALI score of the Cyst+VILI group was lower than the VILI group, but the difference was not statistically significant (P = 0.105). These results suggest potential roles of TG2 in the pathogenesis of VILI.

Indexed as

Acute Lung InjuryAnimalsCystamineCytokinesEnzyme InhibitorsEnzyme-Linked Immunosorbent AssayGene ExpressionGTP-Binding ProteinsLipopolysaccharidesMaleMiceMice, Inbred C57BLNF-kappa BProtein Glutamine gamma Glutamyltransferase 2Respiration, ArtificialTransglutaminasesCystamineCytokinesEnzyme InhibitorsGTP-Binding ProteinsLipopolysaccharidesNF-kappa BProtein Glutamine gamma Glutamyltransferase 2TransglutaminasesAcute Lung InjuryInflammationRespiration, ArtificialRespiratory Distress Syndrome, AdultTransglutaminase 2Ventilator-Induced Lung Injury

Identifiers

PMID24753704
PMCPMC3991800
OpenAlexW2152002829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.