ArticleProceedings of the National Academy of Sciences of the United States of America2014
A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 1 of them a synthesis that pooled it.
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Who cites it
157 citing papers in PubMed, 1 synthesis or guideline pooled it, 250 citations in OpenAlex.
- Global trends in tick research: a comprehensive visualization and bibliometric study (2015-2024).Frontiers in cellular and infection microbiology · 2025Pooled it
- Viral surveillance beyond detection: JMTV and the need for ensemble approaches in emerging virus discovery.Microbiology spectrum · 2026Article
- Macrogenomic analysis showcases the diversity of tick RNA viruses in Mentougou, Beijing, China.New microbes and new infections · 2026Article
- Concepts of RNA virus evolution for the design of better antiviral countermeasures.Nature reviews. Microbiology · 2026Review
- Novel multigene molecular characterization of avian reovirus strains and associated embryonic pathogenicity.Journal of virology · 2026Article
- Molecular characterisation of emerging tacheng tick virus 2 in ticks collected from livestock and dogs in Türkiye.Experimental & applied acarology · 2026Article
- Detection and phylogenetic characterization of Jingmen tick virus inMicrobiology spectrum · 2026Article
- Virome diversity, evolution, transmission networks, and zoonotic potential of wildlife on the Qinghai-Tibet plateau.NPJ biofilms and microbiomes · 2026Article
- New Data on Ixodid Ticks and Their Infection withTropical medicine and infectious disease · 2026Article
- Benchmarks for taxonomic classification of jingmenviruses and closely related viruses using newly identified genomic sequences.The Journal of general virology · 2026Article
- Metaviromic analysis of Ixodes ticks in Northwestern Russia reveals high viral diversity and novel RNA virus lineages.Scientific reports · 2026Article
- The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.Microbiology spectrum · 2026Article
- Amarilloviruses of Aquatic Animals.Pathogens (Basel, Switzerland) · 2026Review
- Evaluation of the vector competence ofFrontiers in cellular and infection microbiology · 2026Article
- Two TaqMan real-time quantitative PCR assays for the detection of Alongshan virus, a new member of the tick-borne Flaviviridae family.Access microbiology · 2026Article
- Article
- First Detection of Jingmen Tick Virus in Hard Ticks Collected Across Multiple Regions of Italy.Viruses · 2025Article
- Molecular detection of human-derived Jingmenvirus in multiple mosquito species from Yaoundé, Cameroon.Parasites & vectors · 2025Article
- Review
- Expansion of the plant-parasitic nematode RNA viruses: Unprecedented diversity, intron-bearing viruses, and cross-kingdom evolutionary links.NPJ biofilms and microbiomes · 2025Article
97 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although segmented and unsegmented RNA viruses are commonplace, the evolutionary links between these two very different forms of genome organization are unclear. We report the discovery and characterization of a tick-borne virus--Jingmen tick virus (JMTV)--that reveals an unexpected connection between segmented and unsegmented RNA viruses. The JMTV genome comprises four segments, two of which are related to the nonstructural protein genes of the genus Flavivirus (family Flaviviridae), whereas the remaining segments are unique to this virus, have no known homologs, and contain a number of features indicative of structural protein genes. Remarkably, homology searching revealed that sequences related to JMTV were present in the cDNA library from Toxocara canis (dog roundworm; Nematoda), and that shared strong sequence and structural resemblances. Epidemiological studies showed that JMTV is distributed in tick populations across China, especially Rhipicephalus and Haemaphysalis spp., and experiences frequent host-switching and genomic reassortment. To our knowledge, JMTV is the first example of a segmented RNA virus with a genome derived in part from unsegmented viral ancestors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.