ArticleProceedings of the National Academy of Sciences of the United States of America2014
Parallel independent evolution of pathogenicity within the genus Yersinia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed.
- Article
- Comparative pangenome analysis of Yersinia enterocolitica in a one health approach.BMC genomics · 2025Article
- Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008-2022).Applied microbiology and biotechnology · 2025Article
- Genome Analysis of Japanese Yersinia pseudotuberculosis Strains Isolated From Kawasaki Disease Patients and Other Sources and Their Phylogenetic Positions in the Global Y. pseudotuberculosis Population.Microbiology and immunology · 2025Article
- Screening of novel therapeutic targets and chimeric vaccine construction against antibiotic-resistantFrontiers in immunology · 2025Article
- Survival and genomic stability ofFrontiers in cellular and infection microbiology · 2025Article
- Breaking resistance: in silico subtractive and comparative genomics approaches for drug targeting in Bacteroides fragilis.Biotechnology letters · 2024Article
- EAVLD 2024 - 7Italian journal of food safety · 2024Article
- Evolutionary insights into the emergence of virulent Leptospira spirochetes.PLoS pathogens · 2024Article
- The Natural and Clinical History of Plague: From the Ancient Pandemics to Modern Insights.Microorganisms · 2024Review
- Evaluation of 16S rRNA genes sequences and genome-based analysis for identification of non-pathogenicFrontiers in microbiology · 2024Article
- Yersinia pestis genomes reveal plague in Britain 4000 years ago.Nature communications · 2023Article
- Public health implications of Yersinia enterocolitica investigation: an ecological modeling and molecular epidemiology study.Infectious diseases of poverty · 2023Article
- Inhibitory Effect of Select Nitrocompounds and Chlorate againstPathogens (Basel, Switzerland) · 2022Article
- EnteroBase: hierarchical clustering of 100 000s of bacterial genomes into species/subspecies and populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The genus Serratia revisited by genomics.Nature communications · 2022Article
- HAYSTAC: A Bayesian framework for robust and rapid species identification in high-throughput sequencing data.PLoS computational biology · 2022Article
- Contributions of Yersinia pestis outer membrane protein Ail to plague pathogenesis.Current opinion in infectious diseases · 2022Review
- Virulence plasmid pINV as a genetic signature forMicrobial genomics · 2022Article
- Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis.PLoS neglected tropical diseases · 2022Article
32 more citing papers are in PubMed but not listed here.
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Abstract
The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locus ail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.
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