ArticleInternational journal for numerical methods in biomedical engineering2014
Modeling and simulation of the effects of cyclic loading on articular cartilage lesion formation.
Article in International journal for numerical methods in biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- In silico assessment of talus osteochondral lesion size and location on biomechanical load distribution using tilted talar dome planes.Acta orthopaedica et traumatologica turcica · 2025Article
- Article
- Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines.PLoS computational biology · 2023Article
- Diffusion of neutral solutes within human osteoarthritic cartilage: Effect of loading patterns.Journal of orthopaedic translation · 2020Article
- Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Mathematics as a conduit for translational research in post-traumatic osteoarthritis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Article
- Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model.Frontiers in bioengineering and biotechnology · 2016Article
- A validated model of the pro- and anti-inflammatory cytokine balancing act in articular cartilage lesion formation.Frontiers in bioengineering and biotechnology · 2015Article
- Corrigendum: "A Validated Model of the Pro- and Anti-Inflammatory Cytokine Balancing Act in Articular Cartilage Lesion Formation".Frontiers in bioengineering and biotechnology · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We present a model of articular cartilage lesion formation to simulate the effects of cyclic loading. This model extends and modifies the reaction-diffusion-delay model by Graham et al., 2012 for the spread of a lesion formed though a single traumatic event. Our model represents 'implicitly' the effects of loading, meaning through a cyclic sink term in the equations for live cells. Our model forms the basis for in silico studies of cartilage damage relevant to questions in osteoarthritis, for example, that may not be easily answered through in vivo or in vitro studies. Computational results are presented that indicate the impact of differing levels of erythropoietin on articular cartilage lesion abatement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.