ArticleJournal of biomedical materials research. Part A2015
Real time visualization and characterization of platelet deposition under flow onto clinically relevant opaque surfaces.
Article in Journal of biomedical materials research. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- In Vitro and In Silico Characterization of the Aggregation of Thrombi on Textured Ventricular Cannula.Annals of biomedical engineering · 2024Article
- Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024Article
- Influence of shear rate and surface chemistry on thrombus formation in micro-crevice.Journal of biomechanics · 2021Article
- The impact of shear stress on device-induced platelet hemostatic dysfunction relevant to thrombosis and bleeding in mechanically assisted circulation.Artificial organs · 2020Article
- An In Vitro Blood Flow Loop System for Evaluating the Thrombogenicity of Medical Devices and Biomaterials.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- The role of PI3K/Akt signaling pathway in non-physiological shear stress-induced platelet activation.Artificial organs · 2019Article
- Device-induced platelet dysfunction in mechanically assisted circulation increases the risks of thrombosis and bleeding.Artificial organs · 2019Article
- Multi-Constituent Simulation of Thrombus Deposition.Scientific reports · 2017Article
- Intracorporeal Heat Distribution from Fully Implantable Energy Sources for Mechanical Circulatory Support: A Computational Proof-of-Concept Study.Frontiers in bioengineering and biotechnology · 2017Article
- Visualization and analysis of biomaterial-centered thrombus formation within a defined crevice under flow.Biomaterials · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Although the thrombogenic nature of the surfaces of cardiovascular devices is an important aspect of blood biocompatibility, few studies have examined platelet deposition onto opaque materials used for these devices in real time. This is particularly true for the metallic surfaces used in current ventricular assist devices (VADs). Using hemoglobin depleted red blood cells (RBC ghosts) and long working distance optics to visualize platelet deposition, we sought to perform such an evaluation. Fluorescently labeled platelets mixed with human RBC ghosts were perfused across six opaque materials (a titanium alloy (Ti6Al4V), silicon carbide (SiC), alumina (Al2O3, 2-methacryloyloxyethyl phosphorylcholine polymer coated Ti6Al4V (MPC-Ti6Al4V), yttria partially stabilized zirconia (YZTP), and zirconia toughened alumina (ZTA)) for 5 min at wall shear rates of 400 and 1000 s(-1). Ti6Al4V had significantly increased platelet deposition relative to MPC-Ti6Al4V, Al2 O3 , YZTP, and ZTA at both wall shear rates (p < 0.01). For all test surfaces, increasing the wall shear rate produced a trend of decreased platelet adhesion. The described system can be a utilized as a tool for comparative analysis of candidate blood-contacting materials with acute blood contact.
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