ArticleMovement disorders : official journal of the Movement Disorder Society2014
Prospective study of obesity, hypertension, high cholesterol, and risk of restless legs syndrome.
Article in Movement disorders : official journal of the Movement Disorder Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- The global and regional prevalence of restless legs syndrome among adults: A systematic review and modelling analysis.Journal of global health · 2024Pooled it
- Restless legs syndrome associated with major diseases: A systematic review and new concept.Neurology · 2016Pooled it
- Sleep Disorders and Stroke: Pathophysiological Links, Clinical Implications, and Management Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- The Correlation Between Sleep and Coronary Heart Disease: A Review.Reviews in cardiovascular medicine · 2025Review
- Article
- Sleep related movement disorders in the elderly: a review of recent literature.Frontiers in sleep · 2024Review
- Restless legs syndrome.Nature reviews. Disease primers · 2021Review
- New onset of restless legs syndrome in pregnancy in a prospective multiracial cohort: Incidence and risk factors.Neurology · 2020Article
- Risk factors for restless legs syndrome in hemodialysis patients in Taiwan: A case-control study.Medicine · 2019Observational
- Blood pressure profile and endothelial function in restless legs syndrome.Scientific reports · 2019Article
- Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study.PLoS medicine · 2018Article
- Article
- Higher Prevalence of Hypertension among Individuals with Restless Legs Syndrome: A Meta-Analysis.Psychiatry investigation · 2018Article
- Periodic limb movements during sleep in stroke/TIA: Prevalence, course, and cardiovascular burden.Neurology · 2018Article
- Evaluation of Cardiovascular Risk Factors and Restless Legs Syndrome in Women and Men: A Preliminary Population-Based Study in China.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Article
- Article
- Nocturnal systolic blood pressure is increased in restless legs syndrome.Sleep & breathing = Schlaf & Atmung · 2016Article
- Restless Legs Syndrome in Patients with Hypertension and Diabetes Mellitus.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Observational
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Because previous cross-sectional studies suggest an association between metabolic disorders and restless legs syndrome (RLS), we prospectively evaluated whether obesity, hypercholesterolemia, and hypertension were associated with increased risk of RLS. Our study consisted of 42,728 female participants from the Nurses' Health Study II and 12,812 male participants from the Health Professionals Follow-up Study, free of RLS at baseline (2002 for men and 2005 for women), and free of diabetes and arthritis through follow-up (2002-2008 for men and 2005-2009 for women). RLS symptoms were assessed using the International RLS Study Group's standardized questionnaire. We considered RLS symptoms a "case" if the symptoms occurred ≥5 times/month and met International RLS Study Group criteria. We found that obesity was associated with an increased risk RLS among both men and women (P difference for sex >0.5). The pooled multivariate-adjusted odds ratio (OR) for RLS was 1.57 (95% confidence interval [CI]: 1.33-1.85; P trend <0.0001) for body mass index >30 versus ≤23 kg/m(2) and 1.56 (95% CI: 1.29-1.89; P trend = 0.0001) comparing two extreme waist circumference quintiles, adjusting for age, ethnicity, smoking, physical activity, use of antidepressant, and other covariates. A similar significant association was found for high cholesterol; the pooled adjusted OR for total serum cholesterol >240 versus <159 mg/dL was 1.33 (95% CI: 1.11-1.60; P trend = 0.002). There was no significant association between hypertension and RLS risk (adjusted OR: 0.90; 95% CI: 0.79-1.02). In this large, prospective study, we found that obesity and high cholesterol, but not high blood pressure, were significantly associated with an increased risk of developing RLS. © 2014 International Parkinson and Movement Disorder Society.
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Registered trials
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