ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2014
Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling.The Journal of cell biology · 2016Article
- Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary.Journal of cell science · 2016Article
- Tomographic Study of the Malformation Complex in Correlation With the Genotype in Patients With Robinow Syndrome: Review Article.Journal of investigative medicine high impact case reportsReview
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4 authors at 1 institution in 1 country.
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Abstract
backgroundThe noncanonical Wnt receptor and tyrosine kinase Ror2 has been associated with recessive Robinow syndrome (RRS) and dominant brachydactyly type B1. The phenotypes of mouse mutants implicate Ror2 in the development of the heart, lungs, bone, and craniofacial structures, which are affected in RRS. Following a recently identified role of Ror2 in the migration of mouse primordial germ cells, we extensively characterized its expression throughout the fetal internal reproductive system and the postnatal ductal system.
resultsWe show that Ror2 gene products are present in the germ cells and somatic cells of the testis and the ovary of both the mouse and human fetus. In reproductive tract structures, we find that Ror2 is expressed in the mesonephros, developing Wolffian and Müllerian ducts, and later in their derivatives, the epididymal epithelium and uterine epithelium.
conclusionsThis study sets the stage to explore function for this tyrosine kinase receptor in novel regions of expression in the developing reproductive system in both mouse and human.
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