ArticleAmerican journal of hematology2014
Risk of diffuse large B-cell lymphoma after solid organ transplantation in the United States.
Article in American journal of hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Immune-related conditions and cancer-specific mortality among older adults with cancer in the United States.International journal of cancer · 2022Pooled it
- Population-level cancer trends among solid organ transplant recipients in the United States during 1995-2021.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Diagnostic Challenges in Diffuse Large B-Cell Lymphoma in a Young Liver Transplant Patient with Ulcerative Colitis: A Case Report.The American journal of case reports · 2025Article
- Incidence of rare cancers during the COVID-19 pandemic: a US population-based study.Journal of the National Cancer Institute · 2025Article
- Engineering a solution for allogeneic CAR-T rejection.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Epidemiology and etiology of diffuse large B-cell lymphoma.Seminars in hematology · 2023Article
- Submandibular gland abscess in a kidney transplant recipient: a diagnostic and therapeutic enigma.BMJ case reports · 2023Article
- Circulating immune markers and risks of non-Hodgkin lymphoma subtypes: A pooled analysis.International journal of cancer · 2023Article
- Healthcare system engagement and algorithm-identified cancer incidence following initiation of a new medication.Pharmacoepidemiology and drug safety · 2023Article
- Cancer risk associated with cytomegalovirus infection among solid organ transplant recipients in the United States.Cancer · 2022Article
- Transplant Onconephrology: An Update.Seminars in nephrology · 2022Review
- A rare case of metastatic uterine lymphoma in a renal transplant patient.Radiology case reports · 2021Article
- Association of antiviral prophylaxis and rituximab use with posttransplant lymphoproliferative disorders (PTLDs): A nationwide cohort study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Epidemiologic perspectives on immunosuppressed populations and the immunosurveillance and immunocontainment of cancer.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Review
- Markers of Immune Activation and Inflammation, and Non-Hodgkin Lymphoma: A Meta-Analysis of Prospective Studies.JNCI cancer spectrum · 2018Review
- Donor-specific Antibodies, Immunoglobulin-free Light Chains, and BAFF Levels in Relation to Risk of Late-onset PTLD in Liver Recipients.Transplantation direct · 2018Article
- Incidence and outcomes of primary central nervous system lymphoma in solid organ transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- Contribution of solid organ transplant recipients to the pediatric non-hodgkin lymphoma burden in the United States.Cancer · 2017Article
- Cancer Risk After Pediatric Solid Organ Transplantation.Pediatrics · 2017Article
- HLA and Risk of Diffuse Large B cell Lymphoma After Solid Organ Transplantation.Transplantation · 2016Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Non-Hodgkin lymphoma arising in the context of immunosuppression is an important adverse outcome after solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed subtype of post-transplantation non-Hodgkin lymphoma, but few studies of transplant recipients have examined subtype-specific risks. Therefore, we examined DLBCL risk in the Transplant Cancer Match Study, including registry-based cancer ascertainment among 96,615 solid organ transplants performed from 2000 to 2008. We determined standardized incidence ratios (SIRs) and 95% confidence intervals comparing DLBCL risk in transplant recipients with that in the general population, and used multivariable Poisson regression models to assess the impact of potential risk factors. We identified 321 incident cases of DLBCL, over 12 times more than expected based on general population rates (SIR = 12.6, 95% confidence interval = 11.2-14.0). SIRs were highest in young recipients and those receiving a lung or pancreas/kidney-pancreas transplant, and were greatly elevated for extranodal DLBCLs at the site of the transplantation compared with other sites. DLBCL risk was highest in the first year following transplantation, and SIRs for early-onset DLBCL risk were elevated in association with Epstein-Barr virus-negative serostatus and use of polyclonal antibody induction therapy. In conclusion, associations between recipient and transplant factors and post-transplantation DLBCL risk suggest a complicated interrelationship among multiple risk factors and timing of disease.
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