ArticleMagnetic resonance in medicine2015
In vivo lung morphometry with hyperpolarized (3) He diffusion MRI: reproducibility and the role of diffusion-sensitizing gradient direction.
Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Diffusion weighted hyperpolarizedMagnetic resonance in medicine · 2023Article
- Improving hyperpolarizedNMR in biomedicine · 2022Article
- Validating in vivo hyperpolarizedMagnetic resonance in medicine · 2021Article
- Lung microstructure in adolescent idiopathic scoliosis before and after posterior spinal fusion.PloS one · 2020Article
- 3D diffusion-weightedMagnetic resonance in medicine · 2018Article
- HyperpolarizedJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2017Article
- Diffusion lung imaging with hyperpolarized gas MRI.NMR in biomedicine · 2017Review
- Experimental evidence of age-related adaptive changes in human acinar airways.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Noninvasive quantification of alveolar morphometry in elderly never- and ex-smokers.Physiological reports · 2015Article
- In vivo lung morphometry with accelerated hyperpolarized (3) He diffusion MRI: a preliminary study.Magnetic resonance in medicine · 2015Article
- Microstructural Analysis of Peripheral Lung Tissue through CPMG Inter-Echo Time R2 Dispersion.PloS one · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeLung morphometry with hyperpolarized gas diffusion MRI is a highly sensitive technique for the noninvasive measurement of acinar microstructural parameters traditionally only accessible by histology. The goal of this work is to establish the reproducibility of these measurements in healthy volunteers and their dependence on the direction of the applied diffusion-sensitizing gradient.
methodsHyperpolarized helium-3 ((3) He) lung morphometry MRI was performed on a total of five healthy subjects. Two subjects received duplicate imaging on the same day and three subjects received duplicate imaging after a 4-month or 27-month delay to assess reproducibility. Four subjects repeated the measurement during the same session with different diffusion-sensitizing gradient directions to determine the effect on the parameter estimates.
resultsThe (3) He lung morphometry measurements were reproducible over the short term and long term (e.g., % coefficient of variation [CV] of mean chord length, Lm = 2.1% and 2.9%, respectively) and across different diffusion gradient directions (Lm % CV = 2.6%). Results also show independence of field inhomogeneity effects at 1.5T.
conclusion(3) He lung morphometry is a reproducible technique for measuring acinar microstructure and is effectively independent of the choice of diffusion gradient direction. This provides confidence for the use of this technique to compare populations and treatment efficacy.
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