ArticleMolecular and cellular biology2014
LIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans.
Article in Molecular and cellular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- A simplified intermittent fasting regimen robustly extendsbioRxiv : the preprint server for biology · 2026Article
- The synapsis checkpoint and the LIN-35/DREAM complex promote temperature stress-induced increases in germline apoptosis in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2025Article
- Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in C. elegans.Nature communications · 2025Article
- Methionine Supplementation Alleviates the Germ Cell Apoptosis Increased by Maternal Caffeine Intake in aNutrients · 2024Article
- LIN-35 is necessary in both the soma and germline for preserving fertility in Caenorhabditis elegans under moderate temperature stress.PloS one · 2023Article
- Systematic analysis of long intergenic non-coding RNAs inRNA biology · 2021Article
- Germ cell apoptosis is critical to maintain Caenorhabditis elegans offspring viability in stressful environments.PloS one · 2021Article
- Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans.BMC biology · 2020Article
- Insights Into the Hypometabolic Stage Caused by Prolonged Starvation in L4-AdultFrontiers in cell and developmental biology · 2020Review
- Germ Cell Responses to Stress: The Role of RNP Granules.Frontiers in cell and developmental biology · 2019Review
- Article
- Long Non-Coding RNA DUXAP8 Enhances Renal Cell Carcinoma Progression via Downregulating miR-126.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Article
- Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience.Biology open · 2016Article
- Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch.eLife · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Apoptosis is an important mechanism for maintaining germ line health. In Caenorhabditis elegans, germ cell apoptosis occurs under normal conditions to sustain gonad homeostasis and oocyte quality. Under stress, germ cell apoptosis can be triggered via different pathways, including the following: (i) the CEP-1/p53 pathway, which induces germ cell apoptosis when animals are exposed to DNA damage; (ii) the mitogen-activated protein kinase kinase (MAPKK) pathway, which triggers germ cell apoptosis when animals are exposed to heat shock, oxidative stress, or osmotic stress; and (iii) an unknown mechanism that triggers germ cell apoptosis during starvation. Here, we address how starvation induces germ cell apoptosis. Using polysomal profiling, we found that starvation for 6 h reduces the translationally active ribosomes, which differentially affect the mRNAs of the core apoptotic machinery and some of its regulators. During starvation, lin-35/Rb mRNA increases its expression, resulting in the accumulation of this protein. As a consequence, LIN-35 downregulates the expression of the antiapoptotic gene ced-9/Bcl-2. We observed that the reduced translation of ced-9/Bcl-2 mRNA during food deprivation together with its downregulation drastically affects its protein accumulation. We propose that CED-9/Bcl-2 downregulation via LIN-35/Rb triggers germ cell apoptosis in C. elegans in response to starvation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.