ArticleJournal of biomolecular NMR2014
Sensitivity gains, linearity, and spectral reproducibility in nonuniformly sampled multidimensional MAS NMR spectra of high dynamic range.
Article in Journal of biomolecular NMR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Decoherence Principles and Algorithms for One-Dimensional Nonuniform Sampling Schedules for Multidimensional NMR.Analytical chemistry · 2025Article
- Enhancing Spectrometer Performance with Unsupervised Machine Learning.The journal of physical chemistry. B · 2024Article
- Cross polarization stability in multidimensional NMR spectroscopy of biological solids.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024Article
- 5D solid-state NMR spectroscopy for facilitated resonance assignment.Journal of biomolecular NMR · 2023Article
- Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction.Journal of biomolecular NMR · 2023Article
- High fidelity sampling schedules for NMR spectra of high dynamic range.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Non-Uniform Sampling in NMR Spectroscopy and the Preservation of Spectral Knowledge in the Time and Frequency Domains.The journal of physical chemistry. A · 2020Article
- Evaluation of Non-Uniform Sampling 2DMetabolites · 2020Article
- Sensitivity boosts by the CPMAS CryoProbe for challenging biological assemblies.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Proton-detected polarization optimized experiments (POE) using ultrafast magic angle spinning solid-state NMR: Multi-acquisition of membrane protein spectra.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- NMR of Macromolecular Assemblies and Machines at 1 GHz and Beyond: New Transformative Opportunities for Molecular Structural Biology.Methods in molecular biology (Clifton, N.J.) · 2018Review
- Applications of NMR to membrane proteins.Archives of biochemistry and biophysics · 2017Review
- Bacteriophage Tail-Tube Assembly Studied by Proton-Detected 4D Solid-State NMR.Angewandte Chemie (International ed. in English) · 2017Article
- GdJournal of biomolecular NMR · 2017Article
- Evolution of CPMAS under fast magic-angle-spinning at 100 kHz and beyond.Solid state nuclear magnetic resonance · 2015Article
- Sensitivity of nonuniform sampling NMR.The journal of physical chemistry. B · 2015Article
- Magic angle spinning NMR spectroscopy: a versatile technique for structural and dynamic analysis of solid-phase systems.Analytical chemistry · 2015Article
- Magic angle spinning NMR of viruses.Progress in nuclear magnetic resonance spectroscopy · 2015Review
- MAS NMR of HIV-1 protein assemblies.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
Recently, we have demonstrated that considerable inherent sensitivity gains are attained in MAS NMR spectra acquired by nonuniform sampling (NUS) and introduced maximum entropy interpolation (MINT) processing that assures the linearity of transformation between the time and frequency domains. In this report, we examine the utility of the NUS/MINT approach in multidimensional datasets possessing high dynamic range, such as homonuclear (13)C-(13)C correlation spectra. We demonstrate on model compounds and on 1-73-(U-(13)C,(15)N)/74-108-(U-(15)N) E. coli thioredoxin reassembly, that with appropriately constructed 50% NUS schedules inherent sensitivity gains of 1.7-2.1-fold are readily reached in such datasets. We show that both linearity and line width are retained under these experimental conditions throughout the entire dynamic range of the signals. Furthermore, we demonstrate that the reproducibility of the peak intensities is excellent in the NUS/MINT approach when experiments are repeated multiple times and identical experimental and processing conditions are employed. Finally, we discuss the principles for design and implementation of random exponentially biased NUS sampling schedules for homonuclear (13)C-(13)C MAS correlation experiments that yield high-quality artifact-free datasets.
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